Optimal Cutoff Values of Skeletal Muscle Index to Define Sarcopenia for Prediction of Survival in Patients with Advanced Gastric Cancer

Annals of Surgical Oncology
Tatsuto NishigoriYoshiharu Sakai

Abstract

Sarcopenia, characterized by loss of skeletal muscle mass, is recognized as a prognostic factor in patients with gastric cancer. However, wide variability exists in the cutoff values of muscle mass for defining sarcopenia across previous studies, and the best cutoff values to predict survival remain unknown. This study aimed to determine the optimal cutoff values for sarcopenia to predict survival in patients with advanced gastric cancer. Patients with clinical stage II/III gastric cancer who underwent gastrectomy at Kyoto University Hospital were included in the study. The cross-sectional area of skeletal muscle at the third lumbar vertebra level was measured using preoperative computed tomography scan. The skeletal muscle index (SMI) was calculated by dividing the area by height in meters squared. Five sex-specific cutoffs of SMI, which were significantly associated with prognosis in patients with gastric and nongastric cancers, were examined as a threshold to define sarcopenia. In the 177 eligible patients, the five cutoffs of SMI resulted in an incidence of sarcopenia between 6 (3%) and 114 (64%). The 5-year overall survival was 48% in patients with sarcopenia based on the cutoffs reported by Martin et al., compared with 68...Continue Reading

References

Jun 1, 1994·Journal of the National Cancer Institute·D G AltmanM Schumacher
Nov 6, 2007·The New England Journal of Medicine·Shinichi SakuramotoUNKNOWN ACTS-GC Group
Oct 17, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marina MourtzakisVickie E Baracos
Nov 6, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin H L TanKenneth C H Fearon
Apr 16, 2010·Age and Ageing·Alfonso J Cruz-JentoftUNKNOWN European Working Group on Sarcopenia in Older People
Jul 9, 2010·Journal of the American College of Surgeons·Hiroshi OkabeYoshiharu Sakai
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Apr 5, 2012·Nature Reviews. Endocrinology·Bente K Pedersen, Mark A Febbraio
Oct 20, 2012·Archives of Gerontology and Geriatrics·Ji-Youn ChungYong-Jae Lee
Mar 27, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa MartinVickie E Baracos
Jun 12, 2013·Journal of Clinical Gastroenterology·Judith Meza-JuncoMichael B Sawyer
Nov 6, 2013·Current Opinion in Supportive and Palliative Care·Sami AntounEmilie Lanoy
Dec 7, 2013·Obesity Research & Clinical Practice·Chia-Wen LuKuo-Chin Huang
May 13, 2014·Journal of Gastroenterology·Soichi IritaniHisataka Moriwaki
Sep 17, 2014·Journal of Cachexia, Sarcopenia and Muscle·Hidetaka Wakabayashi, Kunihiro Sakuma
Dec 17, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B H L TanJ A Catton
Jan 23, 2015·PloS One·Hiroshi FukushimaFumitaka Koga
Aug 21, 2015·The Journal of Urology·Hiroshi FukushimaFumitaka Koga
Aug 26, 2015·Asian Journal of Endoscopic Surgery·Ichiro UyamaTetsu Fukunaga
Nov 26, 2015·Journal of Surgical Oncology·Hiroshi OkabeUNKNOWN Kyoto University Surgical Oncology Group (KUSOG)
Feb 18, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Shlomit Strulov ShacharTomohiro F Nishijima
May 10, 2017·Annals of Surgical Oncology·Katsunobu SakuraiMasaichi Ohira

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Citations

Dec 5, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Huaiying SuLijing Shi
Nov 14, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Emanuele RinninellaMaria Cristina Mele

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