PMID: 2508585Oct 1, 1989Paper

Optimal daily levothyroxine dose in primary hypothyroidism. Its relation to pretreatment thyroid hormone indexes

Archives of Internal Medicine
U M Kabadi

Abstract

Several studies have described the mean optimal replacement daily dose of levothyroxine sodium in subjects with primary hypothyroidism. Furthermore, a cautious approach in replacement therapy of the elderly population is well established. However, the initial dose of levothyroxine has remained variable, especially in young subjects, since the guidelines for the prediction of the final replacement dose are scarce. This study assessed the efficacy of pretreatment thyroid hormone indexes in determination of the final maintenance levothyroxine dose in 156 subjects with primary hypothyroidism. The optimal daily levothyroxine dose as defined by normalization of serum thyroxine and basal thyroid-stimulating hormone levels, as well as thyroid-stimulating hormone response to the intravenous administration of thyrotropin-releasing hormone, varied between 50 micrograms and 200 micrograms and, hence, the subjects were grouped according to the final levothyroxine dose. Significant correlations were noted between the levothyroxine dose for individual groups and pretreatment serum triiodothyronine, thyroxine, and thyroid-stimulating hormone concentrations. However, the serum thyroid-stimulating hormone concentration demonstrated a markedly cl...Continue Reading

Citations

Jan 31, 2004·Thyroid : Official Journal of the American Thyroid Association·Toshihide Yamamoto
Aug 13, 2011·Thyroid : Official Journal of the American Thyroid Association·Jorge RezzonicoGabriela Brenta
Oct 1, 1992·Journal of the American Academy of Nurse Practitioners·J L Johnson, J V Felicetta
Sep 4, 2007·Experimental Gerontology·E FerrariF Magri

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