Optimal definition for PWI/DWI mismatch in acute ischemic stroke patients

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Wataru KakudaDEFUSE Investigators

Abstract

Although the perfusion-weighted imaging/diffusion-weighted imaging (PWI/DWI) mismatch model has been proposed to identify acute stroke patients who benefit from reperfusion therapy, the optimal definition of a mismatch is uncertain. We evaluated the odds ratio for a favorable clinical response in mismatch patients with reperfusion compared with no reperfusion for various mismatch ratio thresholds in patients enrolled in the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. A mismatch ratio of 2.6 provided the highest sensitivity (90%) and specificity (83%) for identifying patients in whom reperfusion was associated with a favorable response. Defining mismatch with a larger PWI/DWI ratio may provide greater power for detecting beneficial effects of reperfusion.

References

Aug 6, 1999·Stroke; a Journal of Cerebral Circulation·T Neumann-HaefelinH J Freund
Oct 8, 1999·Stroke; a Journal of Cerebral Circulation·D G DarbyS M Davis
Jan 10, 2002·Annals of Neurology·Mark W ParsonsStephen M Davis
May 10, 2003·Stroke; a Journal of Cerebral Circulation·Ludy C ShihChelsea S Kidwell
Oct 25, 2003·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellJeffrey L Saver
Dec 13, 2003·Stroke; a Journal of Cerebral Circulation·Vincent N ThijsGregory W Albers
May 26, 2005·Stroke; a Journal of Cerebral Circulation·K S ButcherUNKNOWN EPITHET Investigators
Apr 1, 2006·Stroke; a Journal of Cerebral Circulation·Anthony J FurlanUNKNOWN DEDAS Investigators

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Citations

Apr 24, 2009·Der Radiologe·C RothW Reith
Jul 9, 2008·Current Atherosclerosis Reports·Amie W Hsia, Chelsea S Kidwell
Apr 29, 2010·Current Neurology and Neuroscience Reports·Chelsea S Kidwell, Max Wintermark
Oct 13, 2010·Current Neurology and Neuroscience Reports·Richard E Burgess, Chelsea S Kidwell
Sep 16, 2010·Current Treatment Options in Cardiovascular Medicine·Jean-Marc Olivot, Gregory W Albers
Jun 11, 2009·Brain : a Journal of Neurology·Ferdinand MiteffMark W Parsons
Sep 17, 2013·Brain : a Journal of Neurology·Joyce S BalamiAlastair M Buchan
Dec 26, 2008·Stroke; a Journal of Cerebral Circulation·Jean-Marc OlivotGregory W Albers
Mar 21, 2009·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellUNKNOWN MR IMAGES Investigators
Feb 28, 2009·Stroke; a Journal of Cerebral Circulation·Marc FisherUNKNOWN STAIR Group
May 30, 2009·Stroke; a Journal of Cerebral Circulation·Jeffrey L SaverUNKNOWN STAIR VI Consortium
Apr 28, 2012·Stroke; a Journal of Cerebral Circulation·Greg ZaharchukGregory W Albers
Dec 13, 2012·Stroke; a Journal of Cerebral Circulation·Chelsea S KidwellJeffrey L Saver
Jun 3, 2011·Neurosurgical Focus·Jason S DayBernard R Bendok
Jun 3, 2011·Neurosurgical Focus·E Jesus DuffisChirag Gandhi
Dec 29, 2013·AJNR. American Journal of Neuroradiology·V NambiarB K Menon
Jun 14, 2014·Progress in Nuclear Magnetic Resonance Spectroscopy·Risto A Kauppinen
Mar 13, 2012·Translational Stroke Research·Jinyuan Zhou, Peter C M van Zijl
Nov 28, 2009·AJNR. American Journal of Neuroradiology·A D FurtadoM Wintermark
Sep 1, 2012·Translational Stroke Research·Edwin M NemotoHoward Yonas
Apr 27, 2011·Expert Review of Cardiovascular Therapy·Douglas James Cook, Michael Tymianski
Aug 4, 2011·Expert Review of Cardiovascular Therapy·Albert J YooR Gilberto Gonzalez
Jun 4, 2015·Journal of Magnetic Resonance Imaging : JMRI·Mikkel B HansenKim Mouridsen
Nov 26, 2011·Revue neurologique·J-M Olivot
Jun 7, 2011·Neuroimaging Clinics of North America·William A CopenOna Wu
Jun 7, 2011·Neuroimaging Clinics of North America·Mikayel GrigoryanGregory W Albers
Apr 12, 2011·Neuroimaging Clinics of North America·Albert J Yoo, R Gilberto González
Oct 16, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jason S Day, Harold P Adams
May 2, 2009·Magnetic Resonance Imaging Clinics of North America·Ashley D HarrisRichard Frayne
Apr 19, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jan Sobesky
Dec 6, 2008·Neurologic Clinics·Michael E MoseleyThomas Brosnan
Jan 21, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mark W ParsonsUNKNOWN Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) Investigators
May 13, 2008·Lancet·Geoffrey A DonnanStephen M Davis
Jul 20, 2010·International Journal of Stroke : Official Journal of the International Stroke Society·Wolf-Dieter Heiss
Nov 13, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Bruce C V Campbell, I Mhairi Macrae
Sep 17, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Lorenz BreuerTobias Engelhorn
May 28, 2015·Experimental Neurology·Neeraj ChaudharyGuohua Xi
Nov 26, 2009·Annals of Neurology·David S Liebeskind
Aug 8, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I Q GrunwaldC Roth
Mar 24, 2015·Frontiers in Neurology·Fabien ScalzoDavid S Liebeskind
Jul 12, 2014·AJNR. American Journal of Neuroradiology·M LouJ Sun
Mar 4, 2015·Current Treatment Options in Cardiovascular Medicine·William A Copen

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Software Mentioned

DEFUSE
SPSS

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