Optimal design and characterization of superparamagnetic iron oxide nanoparticles coated with polyvinyl alcohol for targeted delivery and imaging

The Journal of Physical Chemistry. B
Morteza MahmoudiPieter Stroeve

Abstract

Superparamagnetic iron oxide nanoparticles (SPION) with narrow size distribution and stabilized by polyvinyl alcohol (PVA) were synthesized. The particles were prepared by a coprecipitation technique using ferric and ferrous salts with a molar Fe3+/Fe2+ ratio of 2. Using a design of experiments (DOE) approach, the effect of different synthesis parameters (stirring rate and base molarity) on the structure, morphology, saturation magnetization, purity, size, and size distribution of the synthesized magnetite nanoparticles was studied by various analysis techniques including X-ray powder diffraction (XRD), thermogravimetric analysis (TGA) with differential scanning calorimetry (DSC) measurements, vibrating-sample magnetometer (VSM), transmission electron microscopy (TEM), UV-visible, and Fourier transform infrared (FT-IR) spectrometer. PVA not only stabilized the colloid but also played a role in preventing further growth of SPION followed by the formation of large agglomerates by chemisorption on the surface of particles. A rich behavior in particle size, particle formation, and super paramagnetic properties is observed as a function of molarity and stirring conditions. The particle size and the magnetic properties as well as par...Continue Reading

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Citations

Sep 19, 2012·ACS Applied Materials & Interfaces·Hongbo GuZhanhu Guo
Mar 16, 2011·ACS Chemical Neuroscience·Morteza MahmoudiSophie Laurent
Mar 16, 2011·Chemical Reviews·Morteza MahmoudiSophie Laurent
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Apr 12, 2011·Journal of Nanobiotechnology·Małgorzata NowostawskaYurii K Gun'ko
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