PMID: 1751193Jul 1, 1991

Optimal dialysate bicarbonate during hemodialysis

ASAIO Transactions
R Rault


Eleven stable hemodialysis patients were treated with acetate dialysate, then changed to bicarbonate dialysate at three different concentrations. Blood was drawn from the arterial limb of the arteriovenous fistula before and after dialysis for pH, partial pressure of carbon dioxide, bicarbonate radical, and partial pressure of oxygen. Both acetate (35 mEq/L) and the lowest bicarbonate concentration (25 mEq/L) resulted in inadequate control of acid-base balance. Using a bicarbonate concentration of 30 mEq/L, mild predialysis acidosis was still present; this could be abolished using 35 mEq/L, but only at the cost of postdialysis alkalosis and mild hypoxemia.

Related Concepts

Dialysis Solutions
Evaluation of Acid-base Balance
Oxygen Measurement, Partial Pressure, Arterial
Carbonic Acid Ions
Limb Structure
Partial Pressure of Oxygen
Kidney Failure, Chronic
Anion Gap

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