Optimal dosing of miltefosine in children and adults with visceral leishmaniasis.

Antimicrobial Agents and Chemotherapy
Thomas P C DorloPeter J de Vries

Abstract

Only anecdotal data are available on the pharmacokinetics (PK) of miltefosine in children suffering from visceral leishmaniasis (VL). While failure rates were higher in children with VL, steady-state concentrations appeared lower than those seen with adults. We hypothesized that the current linear dosage (in milligrams per kilogram of body weight) is too low for children and that a new dosing algorithm based on an appropriate body size model would result in an optimal exposure. A population PK analysis was performed on three historic pooled data sets, including Indian children, Indian adults, and European adults. Linear and allometric scaling of PK parameters by either body weight or fat-free mass (FFM) was evaluated for body size models. Based on the developed PK model, a dosing algorithm for miltefosine in children and adults was proposed and evaluated in silico. The population PK model employing allometric scaling fitted best to the pooled miltefosine data. Allometric scaling by FFM reduced between-subject variability, e.g., for drug clearance, from 49.6% to 32.1%. A new allometric miltefosine dosing algorithm was proposed. Exposure to miltefosine was lower in children than adults receiving 2.5 mg/kg/day: a C(max) of 18.8 μg...Continue Reading

References

May 1, 1996·Clinical Pharmacokinetics·N H Holford
Dec 10, 1997·Clinical Pharmacokinetics·B J AndersonN H Holford
Dec 16, 1998·Lancet·S SundarH W Murray
Apr 9, 1999·Computer Methods and Programs in Biomedicine·E N Jonsson, M O Karlsson
Dec 10, 1999·The New England Journal of Medicine·T K JhaJ Berman
Mar 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Geoffrey B WestJames H Brown
Jul 27, 2002·BMJ : British Medical Journal·Gavin Yamey, Els Torreele
Nov 29, 2002·The New England Journal of Medicine·Shyam SundarJonathan Berman
Jun 7, 2003·The Pediatric Infectious Disease Journal·Shyam SundarJonathan Berman
Dec 31, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sujit K BhattacharyaJonathan D Berman
Mar 9, 2004·Biochimica Et Biophysica Acta·Michaëlle RakotomangaMichèle Saint-Pierre-Chazalet
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SotoH Sindermann
Jun 24, 2004·Computer Methods and Programs in Biomedicine·Lars LindbomE Niclas Jonsson
Jul 19, 2005·Computer Methods and Programs in Biomedicine·Lars LindbomNiclas Jonsson
Sep 24, 2005·Clinical Pharmacokinetics·Sarayut JanmahasatianBruce Green
Jun 15, 2006·Tropical Medicine & International Health : TM & IH·S P SinghS Sundar
Jul 28, 2006·British Journal of Clinical Pharmacology·Brian J AndersonNicholas H G Holford
Jan 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J SotoJ Berman
Jul 13, 2007·The Journal of Infectious Diseases·Sujit Kumar BhattacharyaNirmal Kumar Ganguly
Aug 11, 2007·BMJ : British Medical Journal·Gavin Yamey, Peter Hotez
Oct 5, 2007·Annual Review of Pharmacology and Toxicology·B J Anderson, N H G Holford
Dec 7, 2007·PLoS Neglected Tropical Diseases·Colin D MathersAlan D Lopez
Mar 8, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Thomas P C DorloJos H Beijnen
Jun 4, 2008·Antimicrobial Agents and Chemotherapy·Thomas P C DorloPeter J de Vries
Sep 13, 2008·PLoS Computational Biology·Van M SavageWalter Fontana
Dec 17, 2008·Diagnostic Microbiology and Infectious Disease·Paul G AmbroseEvelyn Ellis-Grosse
Mar 3, 2009·Drug Metabolism and Pharmacokinetics·Brian J Anderson, Nick H G Holford
May 14, 2009·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Yoav KeynanEthan Rubinstein
Dec 3, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P P A M van ThielP J de Vries
Jan 22, 2010·The Journal of Antimicrobial Chemotherapy·Karin SeifertSimon L Croft
Jan 22, 2010·Clinical Pharmacology and Therapeutics·N Holford
Feb 4, 2010·Journal of Pharmaceutical Sciences·Iftekhar Mahmood
Jul 16, 2010·Computer Methods and Programs in Biomedicine·Ron J KeizerAlwin D R Huitema
Aug 5, 2010·The American Journal of Tropical Medicine and Hygiene·Iván VélezErwin Rodríguez
May 10, 2011·Drug Design, Development and Therapy·Eric Chatelain, Jean-Robert Ioset
May 18, 2011·Antimicrobial Agents and Chemotherapy·G L DrusanoA Louie
Jul 8, 2011·The American Journal of Tropical Medicine and Hygiene·Mahmudur RahmanByron Arana

❮ Previous
Next ❯

Citations

Feb 22, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Suman RijalJean-Claude Dujardin
Aug 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sakib BurzaMaría Angeles Lima
Jul 27, 2012·The Journal of Antimicrobial Chemotherapy·Thomas P C DorloPeter J de Vries
Jan 21, 2014·The Journal of Infectious Diseases·Thomas P C DorloAlwin D R Huitema
Oct 23, 2013·Antimicrobial Agents and Chemotherapy·Ricardo ObonagaNancy Gore Saravia
Feb 23, 2013·Expert Review of Anti-infective Therapy·Sarfaraz Ahmad Ejazi, Nahid Ali
May 8, 2014·Expert Review of Anti-infective Therapy·Manu VanaerschotJean-Claude Dujardin
Mar 5, 2013·Journal of Pharmaceutical Sciences·Rodrigo Alves MoreiraAntonio Alonso
Apr 20, 2014·Journal of Travel Medicine·Johannes BlumDiana N J Lockwood
Dec 21, 2013·Bioorganic & Medicinal Chemistry·Nisha SinghVinod K Tiwari
Jun 30, 2016·The Lancet Infectious Diseases·Thomas P C DorloMarleen Boelaert
Feb 21, 2016·Archives of Disease in Childhood·Eduard E Zijlstra
Aug 1, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Guru R ValicherlaJiaur R Gayen
Dec 15, 2017·PLoS Neglected Tropical Diseases·Alicia Ponte-SucreBarbara Papadopoulou
Sep 7, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jane MbuiFabiana Alves
Oct 16, 2018·Anti-cancer Agents in Medicinal Chemistry·Ferda KaleağasıoğluMartin R Berger
Dec 14, 2016·Antimicrobial Agents and Chemotherapy·María Del Mar CastroNancy Gore Saravia
Dec 4, 2012·Tropical Medicine & International Health : TM & IH·Surendra UranwMarleen Boelaert
Dec 13, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Naomi AronsonAlan Magill
Dec 15, 2018·PLoS Neglected Tropical Diseases·Andrés Uribe-RestrepoMaría Del Mar Castro
Apr 4, 2019·Revista Da Sociedade Brasileira De Medicina Tropical·Raimunda Nonata Ribeiro SampaioCiro Martins Gomes
Aug 23, 2019·The American Journal of Tropical Medicine and Hygiene·Juliana B T CarnielliReynaldo Dietze
Aug 2, 2017·Clinical Pharmacokinetics·Anke E KipThomas P C Dorlo
Jan 23, 2021·RSC Medicinal Chemistry·Sushobhan MukhopadhyaySanjay Batra
Nov 19, 2020·European Journal of Clinical Pharmacology·Roeland E WasmannRob Ter Heine
Oct 27, 2016·Biochimica Et Biophysica Acta. Biomembranes·Kelly Souza FernandesAntonio Alonso
Aug 10, 2021·Frontiers in Cellular and Infection Microbiology·Rodrigo Rollin-PinheiroEliana Barreto-Bergter

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Koert RitmeijerRobert N Davidson
Transactions of the Royal Society of Tropical Medicine and Hygiene
Anthony D M BrycesonG Anabwani
Tropical Medicine & International Health : TM & IH
Surendra UranwMarleen Boelaert
© 2021 Meta ULC. All rights reserved