Optimal duration of prophylactic antibiotic administration for elective colon cancer surgery: A randomized, clinical trial

Surgery
Toshiyuki SuzukiAkemi Kamijo

Abstract

Procedures for perioperative infection prophylaxis in elective colon cancer surgery consist of preoperative mechanical preparation, chemical preparation with oral antibiotic administration, perioperative intravenous antibiotic administration, and others. However, the optimal combination of these procedures and drugs and their durations of administration have not yet been established. A randomized study was conducted to determine the optimal duration of perioperative antibiotic administration with use of mechanical and chemical preparation. A total of 370 patients who were to undergo elective colon cancer surgery were randomized into 2 groups. After mechanical and chemical preparations, a single, 1-g dose of flomoxef was administered immediately before surgery to patients in group A. Flomoxef 1 g was administered twice daily for a total of 4 days from the day of surgery to postoperative day 3 to patients in group B. Comparison was performed between 179 patients in group A and 181 patients in group B with analyzable data. The incidences of incisional surgical site infections (SSIs), organ/space SSIs, and remote infections (RIs) were 15 patients (8.4%), 1 patient (0.6%), and 8 patients (4.5%), respectively, in group A, and 13 pati...Continue Reading

Citations

Sep 6, 2012·ANZ Journal of Surgery·Byung Kyu Ahn, Kang Hong Lee
Feb 26, 2016·Surgical Infections·Patrick B O'Neal, Kamal M F Itani
Nov 7, 2016·The Lancet Infectious Diseases·Benedetta AllegranziUNKNOWN WHO Guidelines Development Group
May 26, 2017·Surgical Infections·Kamal M F ItaniSandra I Berríos-Torres
May 13, 2014·The Cochrane Database of Systematic Reviews·Richard L NelsonMarija Barbateskovic
Jun 14, 2012·Current Opinion in Infectious Diseases·Marin L Schweizer, Loreen A Herwaldt
Dec 15, 2010·Journal of the Korean Society of Coloproctology·Seung Jin Yoo
Feb 23, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·F Pianka, A L Mihaljevic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.