Optimal effect-site concentration of remifentanil for preventing cough during emergence from sevoflurane-remifentanil anaesthesia

Anaesthesia
N H JunY H Shim

Abstract

This randomised, double-blinded, controlled trial was designed to identify the optimal dose of remifentanil for cough suppression without adverse effects during emergence from sevoflurane-remifentanil anaesthesia for thyroidectomy. One hundred and four patients were randomly assigned to maintain target effect-site concentrations of remifentanil at 0 (control group), 1.0 (remifentail 1 group), or 1.5 ng.ml(-1) (remifentanil 1.5 group) during emergence. The incidence of coughing was lower in the remifentanil 1.5 group (31%) than in the control group (74%) or remifentanil 1 group (63%) (p = 0.0004). In addition, the severity of coughing during extubation was lower in the remifentanil 1.5 group (median (IQR [range]) 0 (0-1 [0-1]) than in the control group (1 (0-2 [0-3])) and remifentanil 1 group (1 (0-2 [0-3])) (p = 0.004). Haemodynamic changes were reduced, but emergence time and stay in the post-anaesthesia care unit was prolonged in the remifentanil 1.5 group. Maintaining the remifentanil effect-site concentration at 1.5 ng.ml(-1) during emergence from sevoflurane-remifentanil anaesthesia reduces the incidence and severity of coughing without serious adverse events and may provide haemodynamic stability in patients undergoing th...Continue Reading

Associated Clinical Trials

Mar 17, 2016·LUIS ALBERTO TAFUR B

References

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Citations

Nov 10, 2013·Facial Plastic Surgery Clinics of North America·Vladimir Nekhendzy, Vijay K Ramaiah
Nov 19, 2011·Acta Anaesthesiologica Scandinavica·Y-C YooJ-R Lee
May 21, 2013·The Laryngoscope·Chul Ho ChangYon Hee Shim
Aug 19, 2014·Acta Anaesthesiologica Scandinavica·S Y HamY H Shim
Dec 20, 2014·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Jeong Soo LeeYon Hee Shim
Sep 16, 2017·Journal of Anesthesia·Masanori Tsukamoto, Takeshi Yokoyama

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