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Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-driven Active Rap1a in the RPE

Scientific Reports

Oct 31, 2019

Hai-Bo WangMary Elizabeth R Hartnett

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Abstract

Age-related macular degeneration (AMD) is a multifactorial chronic disease that requires long term treatment. Gene therapy is being considered as a promising tool to treat AMD. We found that increased activation of Rap1a in the retinal pigment epithelium (RPE) reduces oxidative signalin...read more

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Autophagy
Cell Death
Chronic Disease
Gene Therapy
Genetic Vectors
Laboratory mice
Oxidation
Structure of Retinal Pigment Epithelium
NF-kappa B
Promoter
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Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-driven Active Rap1a in the RPE

Scientific Reports

Oct 31, 2019

Hai-Bo WangMary Elizabeth R Hartnett

PMID: 31673119

DOI: 10.1038/s41598-019-52163-z

Abstract

Age-related macular degeneration (AMD) is a multifactorial chronic disease that requires long term treatment. Gene therapy is being considered as a promising tool to treat AMD. We found that increased activation of Rap1a in the retinal pigment epithelium (RPE) reduces oxidative signalin...read more

Mentioned in this Paper

Autophagy
Cell Death
Chronic Disease
Gene Therapy
Genetic Vectors

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