PMID: 25764634Mar 15, 2015Paper

Optimal INR level in Thai atrial fibrillation patients who were receiving warfarin for stroke prevention in Thailand

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Komsing Methavigul, Warangkna Boonyapisit

Abstract

To determine the optimal International Normalized Ratio (INR) level in Thai atrialfibrillation (AF) patients who received warfarin. This retrospective study enrolled 230 AF patients that received warfarin in Siriraj Hospital between January 1, 2005 andDecember 31, 2009 and collected the INR level at the time of the event, the numbers of ischemic stroke, and bleeding events. The incidence density of ischemic stroke or bleeding events was calculated by dividing the number of ischemic stroke or bleeding event in each INR level with the summation of the time that each patient stayed in each INR group. The patients with a prosthetic valve were excluded. The INR range was classified into six groups (less than 1.5, 1.5 to 1.9, 2.0 to 2.4, 2.5 to 2.9, 3.0 to 3.4, and greater than 3.4). The optimal INR level was defined as the lowest incidence density of ischemic stroke and bleeding complications. Two hundred thirty AF patients (the mean age 68 ± 12 years) were enrolled, contributing to 737.54 patient-years of observation period. Of the 230 patients, nine patients experienced 12 ischemic events (1.6 per 100 patient-years) and 54 patients experienced 57 bleeding events (7.7 per 100 patient-years). The percentage of patient-time spent wit...Continue Reading

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