Abstract
Limited data exist on optimal medical therapy post-transcatheter aortic valve implantation (TAVI) for late cardiovascular events prevention. We aimed to evaluate the benefits of beta-blocker (BB), renin-angiotensin system inhibitor (RASi), and their combination on outcomes following successful TAVI. In a consecutive cohort of 1,684 patients with severe aortic stenosis undergoing TAVI, the status of BB and RASi treatment at discharge was collected, and patients were classified into 4 groups: no-treatment, BB alone, RASi alone, and combination groups. The primary outcome was a composite of all-cause mortality and rehospitalization for heart failure (HHF) at 2-year. There were 415 (25%), 462 (27%), 349 (21%), and 458 (27%) patients in no-treatment, BB alone, RASi alone, and combination groups, respectively. The primary outcome was lower in RASi alone (21%; adjusted hazard ratio [HR]adj: 0.58; 95% confidence interval [CI]: 0.42 to 0.81) and combination (22%; HRadj: 0.53; 95% CI: 0.39 to 0.72) groups than in no-treatment group (34%) but no significant difference between RASi alone and combination groups (HRadj: 1.14; 95% CI: 0.80 to 1.62). The primary outcome results were maintained in a sensitivity analysis of patients with reduced...Continue Reading
References
Oct 12, 2005·Circulation·Hongmei PengNour-Eddine Rhaleb
Dec 5, 2006·Journal of Hypertension·Marcus BaumannHarry A J Struijker Boudier
Sep 25, 2010·International Journal of Cardiology·Giovanni CimminoJuan J Badimon
Oct 12, 2010·Circulation Research·Florian LeuschnerMatthias Nahrendorf
Oct 22, 2010·Circulation·Robert W NeumarLaurie J Morrison
Jun 7, 2011·The New England Journal of Medicine·Craig R SmithUNKNOWN PARTNER Trial Investigators
Mar 27, 2012·The New England Journal of Medicine·Raj R MakkarUNKNOWN PARTNER Trial Investigators
Oct 3, 2012·European Heart Journal·A Pieter KappeteinMartin B Leon
Jun 12, 2013·British Journal of Pharmacology·Helen KiriazisXiao-Jun Du
Jul 16, 2013·BMC Cardiovascular Disorders·Muaamar Al-GobariFrançois Gueyffier
Jan 7, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Roberto M LangJens-Uwe Voigt
Apr 5, 2016·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER 2 Investigators
Apr 8, 2017·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Helmut BaumgartnerCatherine M Otto
Apr 12, 2017·The American Journal of Cardiology·Chetan P HudedJames D Flaherty
Oct 8, 2017·Heart·Tomoki OchiaiKentaro Hayashida
Feb 24, 2018·Journal of the American College of Cardiology·Thomas A TreibelJames C Moon
Jul 15, 2018·European Heart Journal Cardiovascular Imaging·Hiske J BrouwerMarc J Claeys
Dec 5, 2018·JAMA : the Journal of the American Medical Association·Taku InoharaSreekanth Vemulapalli
Mar 19, 2019·The New England Journal of Medicine·Jeffrey J PopmaUNKNOWN Evolut Low Risk Trial Investigators
Mar 19, 2019·The New England Journal of Medicine·Michael J MackUNKNOWN PARTNER 3 Investigators
May 1, 2019·The Annals of Thoracic Surgery·Valentino BiancoIbrahim Sultan
Aug 3, 2019·Journal of the American College of Cardiology·Tania Rodriguez-GabellaIgnacio J Amat-Santos
Nov 12, 2019·European Heart Journal·Shmuel ChenMartin B Leon
Jan 30, 2020·The New England Journal of Medicine·Raj R MakkarUNKNOWN PARTNER 2 Investigators
May 16, 2020·Journal of the American College of Cardiology·Katherine H ChauBrian R Lindman
Sep 1, 2020·The New England Journal of Medicine·Jorn BrouwerJurriën M Ten Berg