Optimal methylation noise for best chemotactic performance of E. coli

Physical Review. E
Subrata Dev, Sakuntala Chatterjee

Abstract

In response to a concentration gradient of chemoattractant, E. coli bacterium modulates the rotational bias of flagellar motors which control its run-and-tumble motion, to migrate towards regions of high chemoattractant concentration. Presence of stochastic noise in the biochemical pathway of the cell has important consequences on the switching mechanism of motor bias, which in turn affects the runs and tumbles of the cell in a significant way. We model the intracellular reaction network in terms of coupled time evolution of three stochastic variables-kinase activity, methylation level, and CheY-P protein level-and study the effect of methylation noise on the chemotactic performance of the cell. In presence of a spatially varying nutrient concentration profile, a good chemotactic performance allows the cell to climb up the concentration gradient quickly and localize in the nutrient-rich regions in the long time limit. Our simulations show that the best performance is obtained at an optimal noise strength. While it is expected that chemotaxis will be weaker for very large noise, it is counterintuitive that the performance worsens even when noise level falls below a certain value. We explain this striking result by detailed analy...Continue Reading

References

Apr 1, 1983·Journal of Bacteriology·S M BlockH C Berg
Nov 1, 1982·Cell·S M BlockH C Berg
Jun 1, 1996·Molecular Microbiology·M Eisenbach
Jun 26, 1997·Nature·N Barkai, S Leibler
Jan 29, 1999·Nature·U AlonS Leibler
Aug 17, 2002·Science·Michael B ElowitzPeter S Swain
Nov 15, 2002·Nature·Christopher V RaoAdam P Arkin
Apr 3, 2004·Nature·Ekaterina KorobkovaPhilippe Cluzel
Jun 4, 2004·Journal of Bacteriology·Mingshan Li, Gerald L Hazelbauer
Jul 17, 2004·European Biophysics Journal : EBJ·P-G de Gennes
Nov 13, 2004·Trends in Microbiology·Victor Sourjik
May 27, 2005·Molecular Microbiology·Mingshan Li, Gerald L Hazelbauer
Aug 11, 2005·Physical Review Letters·Yuhai Tu, G Grinstein
Nov 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Bernardo A Mello, Yuhai Tu
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Juan E KeymerNed S Wingreen
Feb 21, 2006·Physical Review Letters·Ekaterina A KorobkovaPhilippe Cluzel
Feb 27, 2008·Proceedings of the National Academy of Sciences of the United States of America·Thierry Emonet, Philippe Cluzel
Apr 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sonja SchulmeisterVictor Sourjik
Jul 23, 2008·Physical Review Letters·Yariv Kafri, Rava Azeredo da Silveira
Sep 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Yuhai TuHoward C Berg
Aug 19, 2009·Biophysical Journal·F MatthäusJ Dobnikar
Oct 27, 2009·Nucleic Acids Research·Ron MiloMichael Springer
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Antonio Celani, Massimo Vergassola
Sep 11, 2010·Nature·Avigdor Eldar, Michael B Elowitz
Apr 16, 2011·PloS One·Franziska MatthäusJure Dobnikar
Nov 22, 2011·Biophysical Journal·Heungwon ParkPhilippe Cluzel
Dec 7, 2011·PLoS Computational Biology·Sakuntala ChatterjeeYariv Kafri
Dec 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Michael W SneddonThierry Emonet
Apr 14, 2012·Nature·Junhua YuanHoward C Berg
Aug 28, 2012·Journal of Molecular Biology·Yuhai Tu, Howard C Berg
Oct 23, 2012·Physical Review Letters·Marlo FloresFilipe Tostevin
Sep 27, 2013·PLoS Computational Biology·William PontiusThierry Emonet
Dec 18, 2013·PLoS Computational Biology·Matthias JeschkeStefan Legewie
Jan 22, 2014·Reports on Progress in Physics·Lev S Tsimring
Jun 27, 2014·PLoS Computational Biology·Yann S DufourThierry Emonet
Oct 4, 2014·ELife·Nicholas W FrankelThierry Emonet
May 15, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Subrata Dev, Sakuntala Chatterjee
Nov 3, 2015·Nature Communications·K M TauteT S Shimizu
Dec 15, 2015·Applied and Environmental Microbiology·Richa KarmakarK V Venkatesh
Jul 28, 2016·Biophysical Journal·Rui HeJunhua Yuan
Sep 7, 2016·PLoS Computational Biology·Yann S DufourThierry Emonet

❮ Previous
Next ❯

Citations

Feb 20, 2019·Physical Review. E·Subrata Dev, Sakuntala Chatterjee
Apr 18, 2021·Physical Review. E·Shobhan Dev Mandal, Sakuntala Chatterjee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physical Review Letters
Marlo FloresFilipe Tostevin
Proceedings of the National Academy of Sciences of the United States of America
Michael W SneddonThierry Emonet
Current Opinion in Cell Biology
Victor Sourjik, Ned S Wingreen
© 2022 Meta ULC. All rights reserved