Optimal sampling of grossly normal omentum in staging of gynecologic malignancies

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Stephanie L Skala, Ian S Hagemann

Abstract

The pathologic detection of microscopic omental metastases is important for the staging and treatment of ovarian and endometrial cancer. The question of how to sample grossly negative omentectomy specimens has not been adequately answered. We reviewed our institutional experience by retrieving a series of gynecologic cancer cases from 1998 to 2013 in which the omentum was grossly negative, but microscopically positive. There were 21 patients with ovarian carcinoma, 7 with ovarian borderline tumors, and 16 with endometrial carcinoma (44 patients in total). Cases in which the omentum was grossly abnormal or suspicious were excluded. A mean of 5.2 blocks were submitted per case (range, 4-15), of which a mean of 2.7 were positive for metastatic disease (range, 1-5). The distribution of cases by percentage of blocks positive was bimodal: some cases showed only 1 or 2 foci of disease in the entire sampled omentum, whereas in other cases nearly every block was positive. Only 3 cases had been sampled with >5 blocks. We used a series of simulated cases, bootstrapped on the retrospective series, to determine the additional sensitivity conferred by submitting >5 blocks. This model indicated that 5 blocks will, in fact, be insufficient to ...Continue Reading

References

Jul 1, 1986·Gynecologic Oncology·J J SteinbergB Bigelow
Jan 6, 2006·The New England Journal of Medicine·Deborah K ArmstrongUNKNOWN Gynecologic Oncology Group
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T Doig, H Monaghan
May 1, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H FujiwaraM Suzuki
Apr 4, 2008·Journal of Cancer Research and Clinical Oncology·Jale Metindir, Gülay Bilir Dilek
Apr 16, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sergio Pecorelli
Jun 24, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Siriwan TangjitgamolJohn Kavanagh
Nov 14, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jaime Prat, UNKNOWN FIGO Committee on Gynecologic Oncology

❮ Previous
Next ❯

Citations

Jan 24, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gloria Cordeiro VidalDenis Querleu
Dec 15, 2018·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Anais MalpicaEsther Oliva
Feb 1, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Gloria Cordeiro VidalDenis Querleu
Feb 14, 2019·Der Pathologe·L-C HornUNKNOWN Kommission zur Erstellung der S3-Leitlinie „Diagnostik, Therapie und Nachsorge der Patientinnen mit Endometriumkarzinom“
May 19, 2020·Gynécologie, Obstétrique, Fertilité & Sénologie·Caroline Eymerit-MorinMojgan Devouassoux-Shisheboran
Feb 1, 2020·Gynécologie, Obstétrique, Fertilité & Sénologie·G CanlorbeC Uzan

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Software Mentioned

Excel
Prism
GraphPad

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.

Related Papers

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
P A GehrigW C Fowler
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
U SaygiliO Erten
© 2021 Meta ULC. All rights reserved