Optimal selection of antiemetics in children receiving cancer chemotherapy

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
F RoilaA Stewart

Abstract

Only a few studies have been carried out specifically on the prevention of nausea and vomiting in children receiving chemotherapy. In these patients older antiemetic drugs such as metoclopramide and phenothiazines had moderate efficacy and induced significant side effects, especially marked sedation and extrapyramidal reactions. In comparative trials the 5-HT3 receptor antagonists have shown better efficacy and tolerability than chlorpromazine or metoclopramide combined with dexamethasone. The combination of a 5-HT3 receptor antagonist plus dexamethasone is superior to a 5-HT3 receptor antagonist alone and should be the standard antiemetic prophylaxis in all paediatric patients receiving highly or moderately emetogenic chemotherapy. The optimal dose and scheduling of these antiemetic drugs need to be studied, as well as the antiemetic efficacy, in the prevention of chemotherapy-induced delayed and anticipatory emesis in children.

Citations

Nov 13, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Fausto RoilaAlexander Molassiotos
Jul 30, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·P C NathanB M Feldman
Mar 28, 2013·Computational and Mathematical Methods in Medicine·Yu-wen LvHai-tao Lv
Nov 11, 1999·Current Opinion in Pediatrics·J S Evans, S Huffman
Jul 28, 2005·Pediatric Blood & Cancer·P Janine PakulisAileen M Davis
Sep 25, 2004·Pediatric Blood & Cancer·Emmanuel S AntonarakisRichard D W Hain
Jul 10, 2003·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·F GibsonN Morgan
Oct 31, 2000·The Annals of Pharmacotherapy·M T HoldsworthS S Winter
May 15, 2012·Behavior Research Methods·Joseph P Magliano, Arthur C Graesser
Aug 1, 2011·Metacognition and Learning·Joseph P MaglianoIrwin Levinstein
Aug 28, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L Lee DupuisMarianne van de Wetering

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.