Optimal sequence of adjuvant endocrine and radiation therapy in early-stage breast cancer - A systematic review

Cancer Treatment Reviews
S F McGeeMark Clemons

Abstract

Clinical equipoise exists around the optimal time to start adjuvant endocrine therapy in patients who will receive post-operative radiotherapy for breast cancer. Concerns continue to exist regarding potential reduced efficacy, or increased toxicity, when radiation, and endocrine therapy are administered concurrently. To perform a systematic review of studies comparing outcomes between sequential and concurrent adjuvant radiation and endocrine therapy in early-stage breast cancer. All modalities of radiation therapy were considered, and endocrine therapy could be either tamoxifen or an aromatase inhibitor. Outcomes of interest included; local, regional or distant recurrence, overall survival and treatment-related toxicities. PubMed, Ovid Medline, EMBASE, and the Cochrane Central Register of Controlled Trials were searched from 1946 to December 2017. Two reviewers independently assessed each citation using the criteria outlined above. Study quality was assessed using the Cochrane Collaboration's tool for prospective studies, and the Newcastle-Ottawa scale for retrospective studies. Of 2137 unique citations identified, 13 met eligibility criteria. Eleven were unique studies (7569 patients), while 2 of the studies were updated anal...Continue Reading

Citations

May 28, 2019·Breast Cancer Research and Treatment·Bassam BasulaimanMark Clemons
Jan 31, 2020·Frontiers in Oncology·Esraa A SalamaHend M El Tayebi
Aug 11, 2020·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·E JouglarS Supiot
Mar 27, 2021·Current Oncology Reports·Max S ManoSamir A Hanna
May 7, 2021·Cancer Treatment and Research Communications·Pablo MandóMatías Chacon

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