Optimal skin prick wheal size for diagnosis of cat allergy

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
Maryam ZareiBruce Goldberg

Abstract

The skin prick test is the diagnostic procedure of choice for determination of immediate hypersensitivity. A wheal diameter of 3 mm or larger is generally accepted as the cutoff for a positive test result, although the validity of this assumption has not been rigorously demonstrated. To determine the skin prick wheal size that best identifies clinical allergy to cat. Forty-five patients referred for evaluation of rhinoconjunctivitis underwent determination of atopic status by skin testing using the Greer Dermapik device and a combination of other modalities, including history, in vitro determination of specific IgE level, and nasal challenge with standardized cat pelt extract. Parameters evaluated before and after nasal challenge included symptom score and nasal lavage tryptase and prostaglandin D (PGD2) levels. The widely accepted 3-mm wheal for a positive skin test result to cat is highly sensitive but only moderately specific for diagnosis of cat allergy as evaluated by history, specific IgE level, postchallenge symptom score, and tryptase and PGD2 levels. Optimal cutoffs for a positive skin test result to cat based on receiver operating characteristic analysis and 95% positive predictive value were 5.5 mm or greater for eac...Continue Reading

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Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology
Jul 9, 2004·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David I Bernstein
Feb 13, 2013·Current Opinion in Allergy and Clinical Immunology·Alessandro FiocchiRichard W Weber
May 3, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Richard W Weber
May 3, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Désirée Larenas-LinnemannRalph Mösges
Sep 23, 2009·Allergologia et immunopathologia·João AntunesPaula Pinto
Mar 16, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C FernándezR Vives
Jun 15, 2013·The Journal of Allergy and Clinical Immunology·Abena S AmoahMaria Yazdanbakhsh
Apr 30, 2016·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Immaculate F NevisConrad Kabali
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Apr 11, 2019·International Archives of Allergy and Immunology·Mona Al-AhmadAbdul Latif Hanoun

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