PMID: 9447654Feb 3, 1998Paper

Optimal statistical design for toxicokinetic studies

Statistical Methods in Medical Research
D A Beatty, W W Piegorsch

Abstract

Optimal statistical design strategies are applied to toxicokinetic experiments, for determining proper allocations of subjects and/or spacings of sampling times under a variety of nonlinear concentration-time models. The strategies include: (i) optimal allocations of subjects assuming the placement of time points is fixed, (ii) optimal spacing of design time points while assuming an equal allocation of subjects per time points and (iii) allocations/time-point spacings optimized jointly. Emphasis is placed on the first case, where a variance-minimization method is illustrated for optimizing the allocations when estimating specific toxicokinetic parameters. Appeals to forms of D-optimality are also considered, for cases when no specific toxicokinetic parameter is of specialized interest.

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Citations

Mar 22, 2006·Journal of Pharmacokinetics and Pharmacodynamics·Ivelina GueorguievaMalcolm Rowland
Dec 14, 2004·Journal of Biopharmaceutical Statistics·Barbara Bogacka, Francis Wright
Feb 3, 1998·Statistical Methods in Medical Research·C Portier, H el Masri

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