Optimal surgery for papillary thyroid carcinoma

World Journal of Surgery
R UdelsmanP Ladenson

Abstract

There has been a long, unresolved debate regarding the operation of choice for well differentiated carcinoma of the thyroid. We therefore analyzed the feasibility, scope, sample size, and length of follow-up required to determine the optimal operation for papillary thyroid carcinoma. A statistical approach was used to design a randomized prospective trial comparing the endpoints of complications, recurrence, and cause-specific mortality. A complication comparison trial is prohibitive owing to the large population required--approximately 12,000 randomized patients. A recurrence trial appears feasible based on sample size: approximately 360 to 800 patients with a 6 to 10-year follow-up. However, recurrence detection would be severely compromised in the lobectomy arm, and a unilateral lag-time bias would occur. A cause-specific mortality trial proves to be the least objectionable, although a large sample size (n = 3100) would be required. Such a trial is critically dependent on the ability to select an appropriate endpoint. A cause-specific mortality trial proves to be the most objective and statistically valid endpoint.

Citations

Jun 1, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A HamyJ-L Kraimps
Jun 3, 2000·The Surgical Clinics of North America·R L RossiR M Rossi
Feb 7, 2008·Nature Clinical Practice. Oncology·Robert Udelsman
Oct 30, 1999·Clinical Otolaryngology and Allied Sciences·R M WalshJ Franklyn
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Tobias Carling, Robert Udelsman
Jan 4, 2007·Thyroid : Official Journal of the American Thyroid Association·Jacqueline JonklaasSteven I Sherman
Sep 24, 2009·Thyroid : Official Journal of the American Thyroid Association·Douglas S RossSteven I Sherman
Feb 9, 2012·Thyroid : Official Journal of the American Thyroid Association·Tobias CarlingUNKNOWN American Thyroid Association Surgical Affairs Committee
Nov 24, 1999·Annals of Surgery·J B FlemingD B Evans
Oct 30, 2009·Current Opinion in Oncology·Tobias CarlingRobert Udelsman
Aug 25, 2007·Annals of Surgery·Karl Y BilimoriaCord Sturgeon
Sep 13, 2012·Journal of Thyroid Research·Sze-How NgBrian Hung-Hin Lang
Aug 13, 2008·Annals of Surgical Oncology·Antonio Toniato
Nov 18, 2011·ISRN Oncology·Marlon A Guerrero, Orlo H Clark
Apr 10, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Davor DžepinaHrvoje Čupić
Apr 12, 2007·World Journal of Surgery·Y Nancy You, Samuel A Wells
Apr 12, 2007·World Journal of Surgery·Jeffrey F Moley, Elizabeth A Fialkowski
Sep 23, 2008·Expert Opinion on Pharmacotherapy·Jennifer A Sipos, Ernest L Mazzaferri
May 15, 2013·Lancet·Donald S A McLeodDavid S Cooper
Apr 29, 2015·Asian Journal of Surgery·Young Woo ChangGil Soo Son
Jun 1, 1996·Surgical Oncology·T W Lennard
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Henning Dralle, Andreas Machens
Oct 29, 2008·Advances in Surgery·Karl Y BilimoriaCord Sturgeon
Nov 26, 2008·American Journal of Otolaryngology·Kimberly A DonnellanRichard O Wein
Feb 3, 2005·The British Journal of Surgery·C PasslerB Niederle
Nov 30, 2006·Journal of Surgical Oncology·Julie Ann Sosa, Robert Udelsman
Nov 13, 2009·Cancer·Henry S ParkJulie Ann Sosa
May 18, 2004·The Surgical Clinics of North America·Alan P B Dackiw, Martha Zeiger
Mar 29, 2000·American Journal of Surgery·S BeenkenH Goepfert
Aug 25, 2015·Advances in Surgery·Christa L JillardJulie Ann Sosa
Feb 24, 2001·Clinical Oncology : a Journal of the Royal College of Radiologists·UNKNOWN Regional Thyroid Cancer Group
Apr 6, 2001·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·D Oertli, F Harder
Mar 12, 2005·Arquivos brasileiros de endocrinologia e metabologia·Pedro Weslley S do RosárioSaulo Purisch
Feb 8, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Neil Bhattacharyya
Jun 22, 2017·Endocrine Reviews·Megan R HaymartJulia Ann Sosa

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