PMID: 20657153Jul 27, 2010Paper

Optimal surgical procedure for locally curative surgery in patients with anaplastic thyroid carcinoma: importance of preoperative ultrasonography

Endocrine Journal
Takuya HigashiyamaAkira Miyauchi

Abstract

Anaplastic thyroid carcinoma (ATC) is a very aggressive disease showing a high mortality. However, long-term survival is expected when patients do not show distant metastasis at diagnosis and undergo locally curative surgery. In this study, we investigated the optimal surgical procedure for locally curative surgery for ATC in a series of 34 patients. Twenty patients underwent total thyroidectomy but there were no detectable skip lesions of ATC in the contralateral lobe on pathological examination. Cause-specific survival (CSS) of Stage IVA or IVB patients who underwent limited thyroidectomy did not differ from that of those who underwent total thyroidectomy. Clinical node metastasis on ultrasonography was not detected in 15 patients but 11 of these patients underwent lymph node dissection. Three of these were node-positive on pathological examination but only one showed metastatic node of ATC that was involved in the primary lesion. Of 19 patients having clinical node metastasis, 10 were ATC node positive on pathological examination. Taken together, for locally curative surgery in ATC patients, 1) total thyroidectomy may not be mandatory unless patients have clinical lesions in the contralateral lobe; 2) prophylactic modified r...Continue Reading

References

Feb 1, 1995·Thyroid : Official Journal of the American Thyroid Association·A AntonelliL Baschieri
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May 23, 2001·World Journal of Surgery·I SugitaniA Yanagisawa
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Aug 16, 2008·Endocrine Journal·Yasuhiro Ito, Akira Miyauchi
Mar 27, 2009·Asian Journal of Surgery·Yasuhiro ItoAkira Miyauchi
Dec 23, 2009·Thyroid : Official Journal of the American Thyroid Association·Takuya HigashiyamaAkira Miyauchi

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Citations

Jan 22, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery·Richard O Wein, Randal S Weber
Dec 6, 2011·Surgery·Clive S Grant, Geoffrey Thompson
Feb 12, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ryan F Brown, Yadranko Ducic
Sep 15, 2012·Journal of the Korean Surgical Society·Eun Mee OhYeo-Kyu Youn
Jun 4, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery

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