Optimal target heart rate for exercise-induced T-wave alternans

Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc
Gioia TurittoNabil El-Sherif

Abstract

This study was conducted to determine the optimal target heart rate (HR) for the use of exercise-induced T-wave alternans (TWA) as an index for risk of malignant ventricular tachyarrhythmias. Rate-dependent TWA is an index of vulnerability to ventricular tachyarrhythmias. However, false positive TWA was reported to occur in normal subjects at high HR. Two groups were evaluated: Group I: 50 patients with malignant ventricular tachyarrhythmias, who received an implantable cardioverter-defibrillator (ICD); and Group II: 55 age-matched normal subjects. In both Groups, TWA was evaluated during symptom-limited bicycle exercise test. Peak HR during exercise test was 103 +/- 17 beats/min in Group I, versus 124 +/- 18 beats/min in Group II (P < 0.001). In Group I, 4 patients were excluded from analysis, due to high noise level or frequent ectopy during exercise. Out of the remaining 46 patients, TWA was present in 28 patients (61%), and absent in 18 (39%). In group II, TWA was present in four subjects (7%), and absent in 51 (93%). HR at the onset of TWA was 91 +/- 11/min in Group I, and 119 +/- 12/min in Group II (P < 0.001). Receiver operated characteristics curves demonstrated that a HR of 115 beats/min was the cutoff with the best se...Continue Reading

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Citations

Apr 14, 2010·Annals of Biomedical Engineering·Violeta MonasterioJuan Pablo Martínez
May 14, 2005·Journal of Electrocardiology·Georgeta D VaideanPentti M Rautaharju
Oct 28, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Esther PueyoPablo Laguna
Jul 13, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Francesco FurlanelloRiccardo Cappato
Jun 24, 2009·Pacing and Clinical Electrophysiology : PACE·John E Madias
Jun 27, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Mário Martins OliveiraJorge Quininha
Aug 18, 2012·Pacing and Clinical Electrophysiology : PACE·Philippe MauryDaniele Marangoni
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Apr 7, 2012·IEEE Transactions on Bio-medical Engineering·Shahriar IravanianDavid J Christini
Apr 14, 2005·IEEE Transactions on Bio-medical Engineering·Juan Pablo Martínez, Salvador Olmos
Nov 8, 2018·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Kenichi HashimotoBonpei Takase
Nov 1, 2001·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·N El-SherifD Robotis
Dec 11, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Faisal M MerchantAntonis A Armoundas
Oct 17, 2019·Journal of the American Heart Association·Kanchan KulkarniAntonis A Armoundas

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