Abstract
This study was conducted to determine the optimal target heart rate (HR) for the use of exercise-induced T-wave alternans (TWA) as an index for risk of malignant ventricular tachyarrhythmias. Rate-dependent TWA is an index of vulnerability to ventricular tachyarrhythmias. However, false positive TWA was reported to occur in normal subjects at high HR. Two groups were evaluated: Group I: 50 patients with malignant ventricular tachyarrhythmias, who received an implantable cardioverter-defibrillator (ICD); and Group II: 55 age-matched normal subjects. In both Groups, TWA was evaluated during symptom-limited bicycle exercise test. Peak HR during exercise test was 103 +/- 17 beats/min in Group I, versus 124 +/- 18 beats/min in Group II (P < 0.001). In Group I, 4 patients were excluded from analysis, due to high noise level or frequent ectopy during exercise. Out of the remaining 46 patients, TWA was present in 28 patients (61%), and absent in 18 (39%). In group II, TWA was present in four subjects (7%), and absent in 51 (93%). HR at the onset of TWA was 91 +/- 11/min in Group I, and 119 +/- 12/min in Group II (P < 0.001). Receiver operated characteristics curves demonstrated that a HR of 115 beats/min was the cutoff with the best se...Continue Reading
References
Jun 1, 1992·Pacing and Clinical Electrophysiology : PACE·M A Habbab, N el-Sherif
Aug 1, 1992·Journal of the American College of Cardiology·B Surawicz, C Fisch
Apr 19, 1991·Science·B D NearingR L Verrier
Jun 3, 1988·Science·J A Swets
Mar 1, 1988·Chest·G Turitto, N El-Sherif
May 1, 1994·Journal of Cardiovascular Electrophysiology·R L Verrier, B D Nearing
Jun 1, 1994·Journal of the American College of Cardiology·W ZarebaW J Hall
Jan 27, 1994·The New England Journal of Medicine·D S RosenbaumR J Cohen
Nov 1, 1996·Journal of Cardiovascular Electrophysiology·D S RosenbaumR J Cohen
Sep 23, 1997·Journal of Cardiovascular Electrophysiology·S H HohnloserR J Cohen
Sep 23, 1997·Journal of Cardiovascular Electrophysiology·R L Verrier, P H Stone
Dec 5, 1997·The American Journal of Cardiology·N A EstesR J Cohen
Apr 30, 1998·Journal of the American College of Cardiology·G GregoratosA Garson
Jul 31, 1998·Journal of Cardiovascular Electrophysiology·N G KaveshM R Gold
Sep 19, 1998·Circulation Research·M ChinushiN El-Sherif
Dec 30, 1998·Journal of Cardiovascular Electrophysiology·S H HohnloserR J Cohen
Aug 10, 1999·Journal of the American College of Cardiology·K AdachiM Yokoyama
Mar 15, 2000·Journal of the American College of Cardiology·T IkedaT Yamaguchi
Citations
Apr 14, 2010·Annals of Biomedical Engineering·Violeta MonasterioJuan Pablo Martínez
May 14, 2005·Journal of Electrocardiology·Georgeta D VaideanPentti M Rautaharju
Oct 28, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Esther PueyoPablo Laguna
Jan 25, 2012·Circulation·Faisal M Merchant, Antonis A Armoundas
Nov 10, 2015·Pacing and Clinical Electrophysiology : PACE·Yuliya KrokhalevaJan Nemec
Jul 13, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Francesco FurlanelloRiccardo Cappato
Jun 24, 2009·Pacing and Clinical Electrophysiology : PACE·John E Madias
Jun 27, 2007·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Mário Martins OliveiraJorge Quininha
Aug 18, 2012·Pacing and Clinical Electrophysiology : PACE·Philippe MauryDaniele Marangoni
Mar 11, 2009·IEEE Transactions on Bio-medical Engineering·Antonis A Armoundas
Nov 8, 2008·IEEE Transactions on Bio-medical Engineering·Iñaki RomeroJames N Watson
Apr 7, 2012·IEEE Transactions on Bio-medical Engineering·Shahriar IravanianDavid J Christini
Apr 14, 2005·IEEE Transactions on Bio-medical Engineering·Juan Pablo Martínez, Salvador Olmos
Sep 17, 2011·Journal of the American College of Cardiology·Richard L VerrierDavid S Rosenbaum
Nov 8, 2018·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Kenichi HashimotoBonpei Takase
Nov 1, 2001·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·N El-SherifD Robotis
Apr 5, 2019·Chinese Medical Journal·She-Liang XueJian-Gang Zou
Jun 18, 2019·Chinese Medical Journal·She-Liang XueJian-Gang Zou
Dec 11, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Faisal M MerchantAntonis A Armoundas
Oct 17, 2019·Journal of the American Heart Association·Kanchan KulkarniAntonis A Armoundas