Optimal temporal decoding of neural population responses in a reaction-time visual detection task

Journal of Neurophysiology
Yuzhi ChenEyal Seidemann

Abstract

Behavioral performance in detection and discrimination tasks is likely to be limited by the quality and nature of the signals carried by populations of neurons in early sensory cortical areas. Here we used voltage-sensitive dye imaging (VSDI) to directly measure neural population responses in the primary visual cortex (V1) of monkeys performing a reaction-time detection task. Focusing on the temporal properties of the population responses, we found that V1 responses are consistent with a stimulus-evoked response with amplitude and latency that depend on target contrast and a stimulus-independent additive noise with long-lasting temporal correlations. The noise had much lower amplitude than the ongoing activity reported previously in anesthetized animals. To understand the implications of these properties for subsequent processing stages that mediate behavior, we derived the Bayesian ideal observer that specifies how to optimally use neural responses in reaction time tasks. Using the ideal observer analysis, we show that 1) the observed temporal correlations limit the performance benefit that can be attained by accumulating V1 responses over time, 2) a simple temporal decorrelation operation with time-lagged excitation and inhib...Continue Reading

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Citations

Jun 27, 2009·Annual Review of Neuroscience·Brian A WiltMark J Schnitzer
Apr 20, 2012·Journal of Neurophysiology·Douglas R OllerenshawGarrett B Stanley
Dec 16, 2011·Journal of Neurophysiology·Chris R PalmerEyal Seidemann
Apr 19, 2012·PLoS Computational Biology·Tom PutzeysRobbe Goris
Jun 21, 2011·PloS One·Wasim Q MalikEmery N Brown
Aug 3, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philipp BerensAndreas S Tolias
May 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Douglas ZhouDavid Cai
Sep 14, 2014·Cerebral Cortex·Mircea I Chelaru, Valentin Dragoi
Oct 6, 2015·Journal of Neuroscience Methods·Hugo RaguetGabriel Peyré
Sep 4, 2012·Current Opinion in Neurobiology·Ranulfo RomoVictor de Lafuente
May 23, 2012·Progress in Neurobiology·Joshua I Gold, Long Ding
Jul 22, 2016·ELife·Eyal SeidemannBoris V Zemelman
Oct 27, 2016·PLoS Computational Biology·Nathalie Van HumbeeckJohan Wagemans
Nov 22, 2016·Neural Computation·Cian O'DonnellTerrence J Sejnowski
Jun 3, 2017·Neurophotonics·Sandrine ChemlaFrédéric Chavane
Mar 20, 2015·Journal of Neurophysiology·He J V ZhengGarrett B Stanley
Feb 26, 2016·Journal of Neurophysiology·Sandrine Chemla, Frédéric Chavane
Aug 25, 2018·Journal of Vision·Robbe L T GorisEero P Simoncelli
Sep 3, 2010·Journal of Neurophysiology·Jungah LeeChoongkil Lee
Jul 6, 2018·Annual Review of Vision Science·Eyal Seidemann, Wilson S Geisler

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