Optimal timing of influenza vaccination in patients with human immunodeficiency virus: a Markov cohort model based on serial study participant hemoagglutination inhibition titers

Vaccine
Gregory R WerkerAslam H Anis

Abstract

Seasonal influenza vaccination offers one of the best population-level protections against influenza-like illness (ILI). For most people, a single dose prior to the flu season offers adequate immunogenicity. HIV+ patients, however, tend to exhibit a shorter period of clinical protection, and therefore may not retain immunogenicity for the entire season. Building on the work of Nosyk et al. (2011) that determined a single dose is the optimal dosing strategy for HIV+ patients, we investigate the optimal time to administer this vaccination. Using data from the "single dose" treatment arm of an RCT conducted at 12 CIHR Canadian HIV Trials Network sites we estimated semimonthly clinical seroprotection levels for a cohort (N=93) based on HAI titer levels. These estimates were combined with CDC attack rate data for the three main strains of seasonal influenza to estimate instances of ILI over different vaccination timing strategies. Using bootstrap resampling of the cohort, nine years of CDC data, and parameter distributions, we developed a Markov cohort model that included probabilistic sensitivity analysis. Cost, quality adjusted life-years (QALYs), and net monetary benefits are presented for each timing strategy. The beginning of D...Continue Reading

References

Jan 1, 1983·Annual Review of Microbiology·R B Couch, J A Kasel
Feb 1, 1993·The American Journal of Medicine·D N RoseH S Sacks
Dec 1, 1993·American Journal of Public Health·K M SullivanI M Longini
Jun 1, 1997·Biologicals : Journal of the International Association of Biological Standardization·J T Martin
Oct 8, 1999·Emerging Infectious Diseases·M I MeltzerK Fukuda
May 4, 2001·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·C B BridgesUNKNOWN Advisory Committee on Immunization Practices
Nov 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jonathan DushoffDavid J D Earn
Feb 9, 2005·Health Economics·Byung Kwang Yoo, Kevin Frick
Mar 11, 2005·Journal of Theoretical Biology·Rajan PatelM Elizabeth Halloran
May 16, 2007·AIDS·Margaret MayUNKNOWN Antiretroviral Therapy (ART) Cohort Collaboration
Jun 5, 2007·Vaccine·Noelle-Angelique M MolinariCarolyn B Bridges
Aug 5, 2008·JAMA : the Journal of the American Medical Association·H Irene HallUNKNOWN HIV Incidence Surveillance Group
Mar 10, 2009·Biologicals : Journal of the International Association of Biological Standardization·Jozef J P NautaAlbert D M E Osterhaus
Apr 11, 2009·Current HIV/AIDS Reports·Heidi M CraneRobert D Harrington
Dec 25, 2009·Emerging Infectious Diseases·Natalie C KleinBurke A Cunha
Aug 18, 2010·Vaccine·Arnold S Monto
Sep 23, 2010·AIDS·Kelly A GeboUNKNOWN HIV Research Network
Apr 23, 2011·PloS One·Curtis CooperUNKNOWN CIHR Canadian HIV Trials Network Influenza Vaccine Research Group
Jun 10, 2011·American Journal of Obstetrics and Gynecology·Evan R MyersGeeta K Swamy
Dec 14, 2011·PloS One·Bohdan NosykUNKNOWN CIHR Canadian HIV Trials Network Influenza Vaccine Research Group
Mar 14, 2012·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Bohdan NosykAslam H Anis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.