PMID: 8602988Feb 1, 1996Paper

Optimal timing of repeated rh-erythropoietin administration improves its effectiveness in stimulating erythropoiesis in healthy volunteers

British Journal of Haematology
C BreymannR Huch

Abstract

We studied the effect of recombinant human erythropoietin (rhEPO) on erythropoiesis when given at different time intervals to healthy adults. 15 volunteers were randomly selected to receive rhEPO (2 x 300 U/kg) and parenteral iron (2 x 200mg) either within a 24 h or 72 h interval. Controls received parenteral iron only. Maximum EPO levels were found 24 h after the first intravenous injection (day 1) with a mean value of 364 and 390 U/l for the rhEPO-treated groups. When second rhEPO administration was after 72 h (group III), volunteers showed significantly higher absolute reticulocyte counts and a higher percentage of young RNA-rich reticulocytes (HFR ratio) over several days compared to those who received rhEPO within a 24 h interval (group II). Both rhEPO-treated groups showed an increase in the mean reticulocyte cell volume. Reticulocyte haemoglobin concentration was inversely correlated with the increasing cell size with a nadir on day 8. Reticulocyte haemoglobin content showed a significant decrease in group II after day 5. Serum ferritin levels showed an inverse pattern to the rate of erythropoiesis. After an initial rise, the serum ferritin decrease was most pronounced in group III. Contrary to previous reports with oral...Continue Reading

Citations

Sep 28, 2001·Journal of Clinical Laboratory Analysis·R S RileyA Tidwell
May 22, 1998·International Journal of Clinical & Laboratory Research·C Brugnara
Mar 22, 2001·Advanced Drug Delivery Reviews·J V Gobburu, W J Jusko
Jun 6, 2000·Advanced Drug Delivery Reviews·W J Jusko, J V Gobburu
Jul 29, 2010·Kidney International·Dmitri Firsov, Olivier Bonny
Jul 4, 2002·Hematology/oncology Clinics of North America·Roger S RileyGina Romagnoli
Jun 10, 2011·Blood·Wolfgang Jelkmann, Carsten Lundby
Aug 10, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·C Breymann
Jan 1, 1998·Hematology·G D'onofrioC Brugnara
Mar 16, 2006·Scandinavian Journal of Clinical and Laboratory Investigation·O DavidC Canavese
Jan 21, 2010·The Journal of Experimental Biology·E M KolbT Garland
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Anatole BesarabAjay Gupta

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