Optimal tumor coverage with different beam energies by IMRT, VMAT and TOMO: Effects on patients with proximal gastric cancer

Medicine
Sheng-Fang HuangWei-Hsiu Liu

Abstract

To compare the effects of different photon energies on radiation planning by intensity-modulated radiotherapy (IMRT), volumetric-modulated arc therapy (VMAT) and helical tomotherapy (TOMO) for proximal gastric cancer (PGC). Network analysis with microarray procession and gene ontology were used to identify the effect of radiotherapy (RT) on PGC. Then, we retrospectively analyzed 8 PGC patients after receiving irradiation with a prescribed dose of 50.4 Gy. The Pinnacle treatment planning system (TPS, V9.8) was used to generate IMRT and VMAT plans by using 6 or 10 MV. TOMO plans were calculated on the Tomotherapy Planning Station Hi-Art Version 4.2.3 workstation (Tomotherapy Incorporated, Madison, WI, USA). PGC is associated with high DNA repair ability. TOMO plan results in higher tumor coverage and a better conformity index than IMRT and VMAT. 10-MV VMAT yields better dosimetric quality of the gradient index than 6-MV VMAT (P = .012). TOMO was associated with a lower irradiation dose in the mean dose to the right kidney (P = .049), left kidney and heart than 6-MV IMRT and 6-MV VMAT. 6-MV IMRT plan presented a higher dose of lung Dmean (P = .017) than 10-MV IMRT. Additionally, VMAT, using a planning energy of 6 MV, was associate...Continue Reading

References

May 17, 2005·Journal of Surgical Oncology·Henk H Hartgrink, Cornelis J H van de Velde
Jul 2, 2005·International Journal of Radiation Oncology, Biology, Physics·Stephen F KryIsaac I Rosen
Jul 5, 2005·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Tilo WiezorekThomas G Wendt
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
Dec 8, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Elisabeth WeissPaul J Keall
Dec 22, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Indira MadaniWilfried De Neve
Feb 9, 2008·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Tilo WiezorekThomas G Wendt
Jan 17, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Stephen F KryDavid Followill
Jun 1, 2010·Journal of Surgical Oncology·Yingqiang Shi, Ye Zhou
Sep 18, 2010·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Jing CaiStanley H Benedict
May 27, 2011·Gut·M Constanza CamargoCharles S Rabkin
Nov 18, 2011·Journal of Applied Clinical Medical Physics·Jong Min ParkSung-Joon Ye
Dec 1, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marlies PaslerJohannes Lutterbach
May 16, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephen R SmalleyJohn S Macdonald
Mar 15, 2013·The New England Journal of Medicine·Sarah C DarbyPer Hall
Jun 1, 2016·The Enzymes·E M BoehmM T Washington
Jun 3, 2016·CA: a Cancer Journal for Clinicians·Kimberly D MillerAhmedin Jemal
Sep 15, 2016·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Cem OnalEsma Efe
May 10, 2017·Environmental and Molecular Mutagenesis·Nimrat Chatterjee, Graham C Walker
Sep 17, 2017·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Stefanie CorradiniClaus Belka

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE29272

Methods Mentioned

BETA
surgical resection

Software Mentioned

TOMO
Statistical Package for Social Sciences ( SPSS )
Art Tomotherapy
STRING
SmartArc
Hi
Pinnacle

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.