Optimal voltage for nanoparticle detection with thin nanopores

The Analyst
Yinghua Qiu

Abstract

The resistive-pulse technique provides a fast and label-free method for nanoparticle detection. To achieve higher sensitivity, thin nanopores such as silicon nitride nanopores are usually considered. In this study, nanoparticle detection has been mimicked with simulations. We found that the surface charges of particles can significantly affect current blockade in short pores, particularly under high electric fields. For particles with surface charge densities higher than -0.02 C m-2, current blockade ratios depend closely on the applied voltage. From our simulation results, an optimal voltage can be found for particle detection, at which the current blockade ratio does not depend on the surface charge density of the particle. This optimal voltage was obtained from the balance of current increase and decrease caused by cations and anions, respectively, due to negative surface charges of the particles. From this systematic study, the optimal voltage was found to represent a property of the system that only depends on the electrolyte type. We think our findings can provide some help for accurate particle detection in experiments.

References

Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J KasianowiczD W Deamer
Dec 26, 2001·Chemical Reviews·Hagan Bayley, Charles R. Martin
Jul 26, 2008·Nature Nanotechnology·Cees Dekker
Oct 1, 2010·Journal of Thrombosis and Haemostasis : JTH·E van der PolR Nieuwland
Mar 23, 2011·Journal of Colloid and Interface Science·Christian SchneiderMatthias Ballauff
May 24, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Rebecca A DragovicIan L Sargent
Aug 20, 2011·Journal of the American Chemical Society·Dmitry Momotenko, Hubert H Girault
Oct 25, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Shivani SharmaJames K Gimzewski
Jun 5, 2012·Physics of Life Reviews·Meni Wanunu
Aug 24, 2012·ACS Nano·Matthew DavenportSonia E Létant
Mar 25, 2014·PloS One·Harold KwokVincent Tabard-Cossa
Jun 5, 2014·Annual Review of Analytical Chemistry·Long LuoHenry S White
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Marina ColomboClotilde Théry
Mar 20, 2015·ACS Nano·Yinghua QiuZuzanna S Siwy
Apr 1, 2015·The Journal of Physical Chemistry. B·Eva Weatherall, Geoff R Willmott
May 15, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Will AndersonMatt Trau
Jul 17, 2015·Analytical Chemistry·Yinghua QiuZuzanna S Siwy
Aug 13, 2015·ACS Nano·Zachary D HarmsStephen C Jacobson
Apr 7, 2016·Analytical Chemistry·Yinghua QiuZuzanna S Siwy
Jul 30, 2016·Analytical Chemistry·Eva WeatherallGeoff R Willmott
May 10, 2017·ACS Nano·Christopher E ArcadiaJacob K Rosenstein
Sep 2, 2017·Scientific Reports·Preston HinkleZuzanna S Siwy

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Citations

Nov 21, 2020·Analytical Chemistry·Long MaYinghua Qiu

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Methods Mentioned

BETA
transmission electron microscopy
flow cytometry
chips
electrophoresis

Software Mentioned

COMSOL
COMSOL Multiphysics

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