Optimal window for ictal blood flow mapping. Insight from the study of discrete temporo-limbic seizures in rats

Epilepsy Research
Serge ChassagnonAstrid Nehlig

Abstract

Measurement of local cerebral blood flow (LCBF) is routinely used to locate the areas involved in the generation and spread of seizures in epileptic patients. Since the spatial distribution and extent of ictal LCBF depends on the epileptogenic network, but also on the timing of injection of tracer, we used a rat model of amygdala kindled seizures to follow time-dependent changes in the distribution of seizure-induced LCBF changes. Rats were implanted with a left amygdala electrode and were stimulated until reaching stage 1. LCBF was measured by the quantitative [14C]iodoantipyrine autoradiographic technique. The tracer was injected either at 15 s before seizure induction (early ictal) or simultaneously with the amygdala stimulation (ictal) in rats undergoing a stage 0 or 1 seizure. During stage 0 seizures, LCBF rates increased significantly ipsilaterally in medial and central amygdala and substantia nigra. During stage 1 seizures, LCBF increased unilaterally in amygdala, piriform cortex, substantia nigra, ventral tegmental area and cerebellum and bilaterally in several limbic and subcortical structures, excepted in hippocampus and pallidum. When pooling stages 0 and 1 but considering only tracer injection time, discrete LCBF ch...Continue Reading

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Citations

Sep 15, 2011·Epilepsia·Jun Young LeeSeung Bong Hong
Jan 11, 2019·International Journal of Molecular Sciences·Sandesh D ReddyDoodipala Samba Reddy
Dec 4, 2019·Experimental Neurology·Heming ChengZhong Chen

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