PMID: 9541846May 2, 1998Paper

Optimal x-ray contrast media for ambulatory coronary angiography from the microcirculatory point of view

Herz
R Bach, F Jung

Abstract

Side effects must be expected in 7 to 8% of cases, even when non-ionic radiocontrast agents are used. Contrast agent-induced microcirculatory disturbances constitute one potential cause under discussion. These disturbances may be caused by either the hyperviscosity or the hyperosmolality of the contrast agents. Within the framework of 3 comparative studies, the influence of viscosity and/or osmolality in intraarterial bolus injections on downstream microcirculation was tested in patients with coronary heart disease. Blood flow in the nailfold capillaries was recorded by intravital videomicroscopy and evaluated off-line, before and after randomized injection of 20 ml of each different radiocontrast agent into the Arteria auxillaries ipsilateral. Injection of 20 ml of a radiographic contrast agent into the Arteria auxillaries with a viscosity of 9.9 mPas and an osmolality of 770 mOsmol/kg H2O (Iopromid with 370 mg iodine/ml) results in a significant reduction in mean erythrocyte velocity in the ipsilateral nailfold capillaries from 0.76 +/- 0.27 to 0.39 +/- 0.31 mm/s after 30 s (p = 0.0001), corresponding to a reduction of 51.3%, whereas electrolyte solution shows no influence. With one exception, all patients reacted with a pron...Continue Reading

References

Jan 1, 1978·Acta Radiologica: Diagnosis·P Aspelin, H Schmid-Schönbein
Sep 1, 1990·Biomedizinische Technik. Biomedical Engineering·F JungG Müller
Nov 1, 1988·Investigative Radiology·H Stormorken
Sep 1, 1987·Biomedizinische Technik. Biomedical Engineering·F JungG Müller

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Citations

Jul 16, 2008·Microvascular Research·Ralf-Peter FrankeFriedrich Jung

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