Optimality and adaptation of phenotypically switching cells in fluctuating environments

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Merzu Kebede Belete, Gábor Balázsi

Abstract

Stochastic switching between alternative phenotypic states is a common cellular survival strategy during unforeseen environmental fluctuations. Cells can switch between different subpopulations that proliferate at different rates in different environments. Optimal population growth is typically assumed to occur when phenotypic switching rates match environmental switching rates. However, it is not well understood how this optimum behaves as a function of the growth rates of phenotypically different cells. In this study, we use mathematical and computational models to test how the actual parameters associated with optimal population growth differ from those assumed to be optimal. We find that the predicted optimum is practically always valid if the environmental durations are long. However, the regime of validity narrows as environmental durations shorten, especially if subpopulation growth rate differences differ from each other (are asymmetric) in two environments. Furthermore, we study the fate of mutants with switching rates previously predicted to be optimal. We find that mutants which match their phenotypic switching rates with the environmental ones can only sweep the population if the assumed optimum is valid, but not ot...Continue Reading

References

Mar 1, 1981·Journal of Bacteriology·M Kihara, R M Macnab
Sep 4, 1999·Molecular Microbiology·I R HendersonJ P Nataro
Aug 17, 2002·Science·Michael B ElowitzPeter S Swain
Feb 20, 2004·Nature·Ertugrul M OzbudakAlexander Van Oudenaarden
May 29, 2004·Genetics·Mukund Thattai, Alexander van Oudenaarden
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·David W Hilbert, Patrick J Piggot
Jul 20, 2004·Clinical Microbiology Reviews·Marjan W van der Woude, Andreas J Bäumler
Aug 17, 2004·Science·Nathalie Q BalabanStanislas Leibler
Feb 3, 2005·Genetics·Edo KussellStanislas Leibler
May 11, 2005·Nature Reviews. Genetics·Mads KaernJames J Collins
May 13, 2005·Nature·Murat AcarAlexander van Oudenaarden
Nov 16, 2005·Annual Review of Genetics·Amos B OppenheimSankar Adhya
Feb 21, 2006·Journal of Theoretical Biology·Nikos V Mantzaris
Jan 12, 2007·Current Opinion in Microbiology·Neeraj Dhar, John D McKinney
Sep 11, 2010·Nature·Avigdor Eldar, Michael B Elowitz
Apr 19, 2012·PLoS Computational Biology·Dmitry NevozhayGábor Balázsi

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Citations

Jan 7, 2017·Mathematical Biosciences·Avan Al-Saffar, Eun-Jin Kim
Dec 20, 2018·In Silico Biology·Daniel A Charlebois, Gábor Balázsi
Oct 29, 2019·PLoS Computational Biology·Mariana Gómez-Schiavon, Nicolas E Buchler
Jun 18, 2017·Physical Review. E·Masaki OguraVictor M Preciado
Jan 23, 2020·Physical Review. E·J Gonzalez-AyalaA Calvo Hernández
Aug 5, 2020·Proceedings of the National Academy of Sciences of the United States of America·Carolyn ZhangLingchong You
Jul 28, 2019·Scientific Reports·Niraj KumarRahul V Kulkarni
Dec 9, 2020·Entropy·Leonardo R GamaAlexandre F Ramos
Nov 9, 2017·Biophysical Journal·Michael G CortesGábor Balázsi

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