Optimally designed nanolayered metal-dielectric particles as probes for massively multiplexed and ultrasensitive molecular assays.

Proceedings of the National Academy of Sciences of the United States of America
Anil K KodaliRohit Bhargava

Abstract

An outstanding challenge in biomedical sciences is to devise a palette of molecular probes that can enable simultaneous and quantitative imaging of tens to hundreds of species down to ultralow concentrations. Addressing this need using surface-enhanced Raman scattering-based probes is potentially possible. Here, we theorize a rational design and optimization strategy to obtain reproducible probes using nanospheres with alternating metal and reporter-filled dielectric layers. The isolation of reporter molecules from metal surfaces suppresses chemical enhancement, and consequently signal enhancements are determined by electromagnetic effects alone. This strategy synergistically couples interstitial surface plasmons and permits the use of almost any molecule as a reporter by eliminating the need for surface attachment. Genetic algorithms are employed to optimize the layer dimensions to provide controllable enhancements exceeding 11 orders of magnitude and of single molecule sensitivity for nonresonant and resonant reporters, respectively. The strategy also provides several other opportunities, including a facile route to tuning the response of these structures to be spectrally flat and localization of the enhancement within a spec...Continue Reading

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Citations

Sep 6, 2007·Analytical and Bioanalytical Chemistry·Rohit Bhargava
Nov 6, 2013·Photochemistry and Photobiology·Brent M DeVetterCatherine J Murphy
Jul 22, 2016·Faraday Discussions·Joshua G HinmanCatherine J Murphy
Mar 18, 2015·Physical Chemistry Chemical Physics : PCCP·B X K ChngP S Carney
Jun 6, 2013·Optics Express·Thomas van DijkP Scott Carney
Sep 11, 2019·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Ilia L RasskazovP Scott Carney
Jul 3, 2013·The Journal of Physical Chemistry Letters·Thomas van DijkP Scott Carney
Apr 17, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Sean T SivapalanCatherine J Murphy
Feb 26, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Shujun ZhouManabu Shimada

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