Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics

Scientific Reports
Andres Ruiz-SolerAmir Keshmiri

Abstract

Graft failure is currently a major concern for medical practitioners in treating Peripheral Vascular Disease (PVD) and Coronary Artery Disease (CAD). It is now widely accepted that unfavourable haemodynamic conditions play an essential role in the formation and development of intimal hyperplasia, which is the main cause of graft failure. This paper uses Computational Fluid Dynamics (CFD) to conduct a parametric study to enhance the design and performance of a novel prosthetic graft, which utilises internal ridge(s) to induce spiral flow. This design is primarily based on the identification of the blood flow as spiral in the whole arterial system and is believed to improve the graft longevity and patency rates at distal graft anastomoses. Four different design parameters were assessed in this work and the trailing edge orientation of the ridge was identified as the most important parameter to induce physiological swirling flow, while the height of the ridge also significantly contributed to the enhanced performance of this type of graft. Building on these conclusions, an enhanced configuration of spiral graft is proposed and compared against conventional and spiral grafts to reaffirm its potential benefits.

References

Nov 30, 1991·Lancet·P A Stonebridge, C M Brophy
Apr 1, 1994·Journal of Applied Physiology·J E MooreP Boesiger
Jul 1, 1996·Clinical Science·P A StonebridgeJ F Belch
May 3, 2000·Journal of Biomechanical Engineering·S J SherwinC L Dumoulin
Nov 7, 2003·Journal of Vascular Surgery·Willemijn M KleinWillem P Th M Mali
Dec 24, 2003·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hiroaki Haruguchi, Satoshi Teraoka
Jul 20, 2006·Journal of the Royal Society, Interface·Colin G CaroNick Watkins
Nov 6, 2008·Medical Image Computing and Computer-assisted Intervention : MICCAI·Ufuk OlgacDims Poulikakos
Jan 17, 2009·Annals of Biomedical Engineering·A N CooksonS J Sherwin
Feb 14, 2009·The Canadian Journal of Cardiology·Pirouz Parang, Rohit Arora
Mar 26, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Tinghui ZhengXiaoyan Deng
Oct 12, 2010·Medical Engineering & Physics·Kyung E LeeJung Y Yoo
Apr 15, 2011·Methodist DeBakey Cardiovascular Journal·Peter A Stonebridge
May 20, 2011·Journal of the Royal Society, Interface·P E VincentS J Sherwin
Aug 19, 2011·IEEE Transactions on Bio-medical Engineering·P SiogkasO Parodi
Jun 12, 2012·Annals of Vascular Surgery·Peter A StonebridgeGraeme Houston
Oct 15, 2013·Ultrasound in Medicine & Biology·Efstratios KokkalisJ Graeme Houston
Dec 18, 2013·Biomedical Engineering Online·Dhanjoo N Ghista, Foad Kabinejadian
Jan 3, 2018·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Michael McElroy, Amir Keshmiri

❮ Previous
Next ❯

Citations

Jan 16, 2020·Annals of Biomedical Engineering·Amin DeyranlouAmir Keshmiri
Sep 3, 2020·Scientific Reports·Kathryn A McGurkBernard D Keavney
Nov 30, 2020·International Journal for Numerical Methods in Biomedical Engineering·Sjeng QuickenWouter Huberts
Aug 1, 2019·Current Cardiology Reviews·Vadim V GenkelIgor I Shaposhnik
Apr 2, 2021·Scientific Reports·Michael McElroyStephen J White
Oct 2, 2021·PloS One·Konstantinos G Lyras, Jack Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
rheology
peripheral artery bypass

Software Mentioned

ANSYS CFX
SwirlGraft
ANSYS
- Meshing

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.