Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography

The British Journal of Ophthalmology
Jiaxu HongJianjiang Xu

Abstract

To present in vivo anterior segment optical coherence tomography (OCT) features of infants with Peters' anomaly obtained during presurgical examination under general anaesthesia, and to evaluate the impact of OCT features on surgical decision making. This is a single-centre, consecutive, observational case series including 44 eyes of 27 infants with Peters' anomaly (5-18 months) undergoing keratoplasty. Medical records of patients were reviewed retrospectively. Clinical features and OCT findings, along with their impact on surgical decision-making were analysed. Of 27 patients, 10 had unilateral and 17 had bilateral disease. Two patients with mild disease (three eyes) had a posterior corneal defect with leukoma (2/27, 7.4%). Twenty patients (32 eyes) with iridocorneal adhesions were classified as having moderate Peters' anomaly (20/27, 74.1%) and five patients (nine eyes) with lenticulocorneal adhesions were classified as having severe Peters' anomaly (5/27, 18.5%). The range of angle closure, anterior chamber depth and maximum iridocorneal adhesion length (all p<0.001) were significantly different among groups, indicating that they might serve as novel OCT parameters for assessing the severity of Peters' anomaly. The surgical ...Continue Reading

References

Feb 1, 1976·American Journal of Ophthalmology·D L StoneS J Ryan
Dec 1, 1992·Archives of Ophthalmology·E I Traboulsi, I H Maumenee
Jun 1, 1992·Ophthalmic Paediatrics and Genetics·U M Mayer
May 1, 1988·International Journal of Pediatric Otorhinolaryngology·C M MyerS Gray
Oct 1, 1971·American Journal of Ophthalmology·I Nakanishi, S I Brown
Dec 29, 2000·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H OzekiY Ogura
Sep 20, 2001·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J P HoopsA Kampik
Oct 20, 2001·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·R M ComerM O'Keefe
Jan 22, 2002·The British Journal of Ophthalmology·K K NischalD S Rootman
Jun 9, 2004·American Journal of Ophthalmology·C K PatelAndrew D Farmery
Sep 18, 2007·Paediatric Respiratory Reviews·Michael D Nissen
Jul 25, 2008·Cornea·Kavita V RaoVirender S Sangwan
Apr 28, 2009·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Lucy L H YangR Doyle Stulting
Jul 6, 2011·American Journal of Ophthalmology·Juha M Holopainen, Kari Krootila
Nov 24, 2011·Journal of Cataract and Refractive Surgery·Kamiar MireskandariAsim Ali
Jul 14, 2012·Cornea·Hassan HashemiMasomeh Mohebi
Sep 11, 2012·Ophthalmology·Anna S MajanderKari Krootila
Oct 12, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ji Woong ChangYoung Suk Yu
Aug 10, 2013·Clinical & Experimental Ophthalmology·Naoyuki MorishigeKoh-Hei Sonoda
Dec 4, 2013·Journal of Clinical and Diagnostic Research : JCDR·Veena Bhardwaj, Gandhi Parth Rajeshbhai
Jan 18, 2014·Clinical & Experimental Ophthalmology·Yoko A Ito, Michael A Walter
Jul 24, 2014·Investigative Ophthalmology & Visual Science·Yujing YangJianjiang Xu
Oct 18, 2014·Seminars in Ophthalmology·Ramez I Haddadin, James Chodosh
Jul 11, 2015·Ophthalmology·Sebastian SiebelmannClaus Cursiefen
Aug 1, 2015·JAMA Ophthalmology·Sebastian SiebelmannClaus Cursiefen
Nov 1, 2015·Progress in Brain Research·Fang KoPeng T Khaw

Citations

Dec 19, 2017·The Journal of Veterinary Medical Science·Sangwan ParkKangmoon Seo
Jul 5, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Sebastian SiebelmannClaus Cursiefen
Dec 12, 2018·International Ophthalmology·Carla J OsigianMohamed Abou Shousha
Jul 28, 2020·Survey of Ophthalmology·Jeewan S TitiyalNamrata Sharma

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.