Optimising nutrition in chronic renal insufficiency--progression of disease

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
L J NormanA R Watson

Abstract

There is a lack of evidence to support the belief that dietary measures are beneficial in slowing the progression of chronic renal insufficiency (CRI). We prospectively monitored nutrient intakes and progression of CRI over a 2-year period in children aged 2-16 years with differing levels of severity of CRI, as part of their ongoing joint medical/dietetic care. Children were grouped following [5'Cr]-labelled EDTA glomerular filtration rate(GFR, ml/min per 1.73 m 2) estimations, into 'normal'kidney function [GFR >75, mean 106 (SD 19.5), n=58],providing baseline data only, mild (GFR 51-75, n=25),moderate (GFR 25-50, n =21), and severe (GFR <25, n=19) CRI. Children with CRI were followed for 2 years,with 51 completing the study (19 mild, 19 moderate, 13 severe CRI) and were excluded if they subsequently required dialysis. Regular medical and dietary advice was provided and yearly 3-day semi-quantitative dietary di-aries and baseline and 6-monthly measurements of blood pressure and urinary protein/creatinine ratio were obtained. Mean reductions in estimated GFR over 2 years were -9.4, -5.8, and -6.0 ml/min per 1.73 m2 for mild,moderate, and severe CRI, respectively. Mean systolic blood pressure standard deviation score (SDS) fell s...Continue Reading

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Citations

Jun 15, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tim Ulinski, Pierre Cochat
Jan 12, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees, Vanessa Shaw
Feb 23, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Poyyapakkam R SrivathsStuart L Goldstein
Jul 25, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees, Helen Jones
Jan 22, 2010·Current Opinion in Pediatrics·Amy Staples, Craig Wong
Oct 28, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Russell W ChesneyNorman J Siegel
Oct 19, 2007·The Cochrane Database of Systematic Reviews·S Chaturvedi, C Jones
May 13, 2014·Journal of Renal Care·Aggeliki Apostolou, Tauhomai Karagiozoglou-Lampoudi
May 10, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Louise McAlisterRukshana Shroff

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