Optimising the biocompatibility of 3D printed photopolymer constructs in vitro and in vivo

Biomedical Materials
C G Y NganP F M Choong

Abstract

3D printing is a rapid and accessible fabrication technology that engenders creative custom design solutions for cell scaffolds, perfusion systems and cell culture systems for tissue engineering. Critical to its success is the biocompatibility of the materials used, which should allow long-term tissue culture without affecting cell viability or inducing an inflammatory response for in vitro and in vivo applications. Polyjet 3D printers offer arguably the highest resolution with the fewest design constraints of any commercially available 3D printing systems. Although widely used for rapid-prototyping of medical devices and 3D anatomical modelling, polyjet printing has not been adopted by the tissue engineering field, largely due to the cytotoxicity of leachates from the printed parts. Biocompatibility in the context of cell culture is not commonly addressed for polyjet materials, as they tend to be optimised for their ability to fabricate complex structures. In order to study the potential issues surrounding the leaching of toxins, we prepared cell culture substrates using the commercially available MED610 photopolymer. The substrates were cleaned using either the manufacturer-specified 'biocompatible' washing procedures, or a n...Continue Reading

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Citations

Aug 18, 2020·The Journal of Craniofacial Surgery·Prabhat Kumar Chaudhari, Kunaal Dhingra
Nov 7, 2019·Micromachines·Jia Ming ZhangHuiling Duan
Nov 12, 2020·Advanced Engineering Materials·Louis A van der ElstAlexander Gumennik

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