Optimising the use of cetuximab in the continuum of care for patients with metastatic colorectal cancer.

ESMO Open
Richard M GoldbergDaniele Santini

Abstract

The anti-epidermal growth factor receptor (EGFR) monoclonal antibody cetuximab in combination with chemotherapy is a standard of care in the first-line treatment of RAS wild-type (wt) metastatic colorectal cancer (mCRC) and has demonstrated efficacy in later lines. Progressive disease (PD) occurs when tumours develop resistance to a therapy, although controversy remains about whether PD on a combination of chemotherapy and targeted agents implies resistance to both components. Here, we propose that some patients may gain additional clinical benefit from the reuse of cetuximab after having PD on regimens including cetuximab in an earlier treatment line. We conducted a non-systematic literature search in PubMed and reviewed published and ongoing clinical trials, focusing on later-line cetuximab reuse in patients with mCRC. Evidence from multiple studies suggests that cetuximab can be an efficacious and tolerable treatment when continued or when fit patients with mCRC are retreated with it after a break from anti-EGFR therapy. Furthermore, on the basis of available preclinical and clinical evidence, we propose that longitudinal monitoring of RAS status may identify patients suitable for such a strategy. Patients who experience pro...Continue Reading

References

Jul 1, 1990·Cancer Causes & Control : CCC·R CapocacciaF Berrino
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·B Vogelstein, K W Kinzler
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Devin DressmanBert Vogelstein
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel VallböhmerHeinz-Josef Lenz
Apr 13, 2007·Expert Review of Anticancer Therapy·Marian Gil DelgadoDavid Khayat
Apr 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alberto F SobreroHoward A Burris
Aug 13, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roberto BiancoGiampaolo Tortora
Oct 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hansjochen WilkeSalvatore Siena
Sep 10, 2009·Journal of the National Cancer Institute·Salvatore SienaAlberto Bardelli
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc PeetersJennifer Gansert
Nov 26, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David LiskaMartin R Weiser
Apr 30, 2011·World Journal of Gastroenterology : WJG·Robert LimSuresh Advani
Jul 19, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Emmanuelle NorguetJean-François Seitz
Mar 8, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D SantiniG Tonini
Jun 1, 2012·Science Translational Medicine·Tim ForshewNitzan Rosenfeld
Dec 6, 2012·Journal of Gastrointestinal Cancer·Akito HataKazuki Terashima
Oct 22, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Josep TaberneroCarmen J Allegra
Nov 20, 2013·Journal of Experimental & Clinical Cancer Research : CR·Giuseppe ToniniDaniele Santini
Dec 21, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M PeetersR Sidhu
Feb 21, 2014·Science Translational Medicine·Chetan BettegowdaLuis A Diaz
Sep 24, 2014·Neoplasia : an International Journal for Oncology Research·Giampietro GaspariniAntonio Marchetti
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemFortunato Ciardiello
Jan 28, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabrina ArenaClara Montagut
Jan 30, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M P MorelliS Kopetz
Jan 30, 2015·Clinical Medicine Insights. Oncology·Prakash PeddiSyed H Jafri
Feb 13, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Filippo PietrantonioSandro Barni
Feb 17, 2015·Future Oncology·Luisa FoltranGianpiero Fasola

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Citations

Dec 29, 2018·Expert Opinion on Pharmacotherapy·Cathy Eng, Jane E Rogers
Jul 11, 2020·Cancer Metastasis Reviews·Gábor LakatosGyörgy Bodoky
Apr 11, 2019·Frontiers in Oncology·Franciele H KnebelDenis L Jardim
Jan 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ralph El HallalYuling Wang
May 1, 2021·Cancers·Davide CiardielloErika Martinelli
Jul 18, 2021·Oncogenesis·Dedrick Kok Hong Chan, Simon James Alexander Buczacki
Sep 10, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Sridhar MuthusamiIlangovan Ramachandran

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Methods Mentioned

BETA
biopsy
biopsies
PCR
genetic modifications

Clinical Trials Mentioned

NCT02337946
NCT02296203
NCT02934529

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