Optimization and characterization of a pH-independent extended-release hydrophilic matrix tablet

Pharmaceutical Development and Technology
P TimminsJ R Howard

Abstract

A simple systematic optimization approach was applied to tailor the drug release profile from a hydrophilic matrix extended-release tablet. When the ratio of anionic and nonionic polymers was optimized, pH-independent in vitro release of the model drug verapamil hydrochloride was obtained. The mechanisms of drug release at the pH extremes were evaluated by graphical analysis of the dissolution data and direct examination of the tablets during dissolution. Graphical evaluation did not completely clarify the release control mechanisms involved. Direct examination of tablets during dissolution, with estimation of amounts of drug and excipients dissolved at different times, gave further insight into relative contribution of mechanisms at different pH values. The change from predominantly diffusional to predominantly erosional mechanisms as pH is increased provides for the pH-independent release observed. This understanding should help model the application of this approach to other drugs.

References

Aug 1, 1966·Journal of Pharmaceutical Sciences·H Lapidus, N G Lordi
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Citations

Jul 24, 2008·Pharmaceutical Development and Technology·Bistra KostovaGeorge Georgiev
Jun 5, 2003·Drug Development and Industrial Pharmacy·Dale L Munday
Aug 23, 2008·Drug Development and Industrial Pharmacy·S GutscheH Kranz
Apr 25, 2007·Drug Development and Industrial Pharmacy·C GuthmannH Kranz
Dec 22, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Martin KuentzDavid P Elder
Jun 23, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A DashevskyR Bodmeier
Aug 16, 2015·International Journal of Pharmaceutics·Nizar Al-ZoubiStavros Malamataris
Jan 30, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·C GuthmannH Kranz
Mar 17, 2017·Pharmaceutical Development and Technology·Samuel PygallColin Melia
Jan 1, 2008·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Bistra Kostova, Dimitar Rachev
Oct 16, 2012·Biopharmaceutics & Drug Disposition·Sarah J NicholsonIan Wilding
Jan 12, 2021·Frontiers in Chemistry·Gabriela A FernándezLucia V Cavallaro

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