Optimization and characterization of electrospun polycaprolactone coated with gelatin-silver nanoparticles for wound healing application

Materials Science & Engineering. C, Materials for Biological Applications
Nhi Tra ThanhHiep Nguyen Thi

Abstract

Bacterial infection and damage caused by dressing removal are two concerning problems which prolong the healing process in treatment of skin injuries. In this study, plasma treated electrospun polycaprolactone (PCL) scaffold was coated with silver nanoparticles (AgNPs) embedded in gelatin (Gel) by multi-immersion technique to optimize its antibacterial performance and reduce wound-scaffold adhesion. Water interaction test was used to examine the hydrophilization of PCL electrospun fibers after plasma treatment. Scanning Electron Microscopy (SEM) and weight calculation were employed to investigate the morphology and absorptive ability of the GelAg multi-coated PCL membrane (EsPCLGelAg). Antibacterial property of the membrane was evaluated using agar diffusion method against gram positive and gram negative bacteria. Mice model was also used to examine the efficiency of the membrane in healing process and its ability to prevent damage of newly formed tissue when peeling off. SEM results showed that the thickness of GelAg layer on EsPCL membrane increases correspondingly to the number of coating times. In vitro and in vivo data also demonstrated that the greater number of GelAg coating times, the more significant the antibacterial ...Continue Reading

Citations

Jan 17, 2020·Nanoscale·Katayoon KalantariThomas J Webster
Feb 1, 2019·Burns and Trauma·Rachael Zoe MurrayBrooke Louise Farrugia
Oct 30, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xize GaoJun Wu
May 10, 2019·Science and Technology of Advanced Materials·Ly Loan KhanhNguyen Thi Hiep
Apr 9, 2020·Frontiers in Bioengineering and Biotechnology·Fengxuan HanBin Li
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Trinh Thi-Phuong HoThi-Hiep Nguyen
Jun 4, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Giorgia PagnottaChiara Gualandi
Jul 3, 2020·Current Pharmaceutical Design·Ameya SharmaInderbir Singh
Jun 1, 2021·ACS Applied Bio Materials·Lai Jiang, Say Chye Joachim Loo
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muhammad ZahidDorota Siuta

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