Optimization for extracellular biosynthesis of silver nanoparticles by Penicillium aculeatum Su1 and their antimicrobial activity and cytotoxic effect compared with silver ions

Materials Science & Engineering. C, Materials for Biological Applications
Liang MaJian-Xin Tang

Abstract

The present study addresses an eco-friendly and energy-saving method for extracellular biosynthesis of silver nanoparticles (AgNPs) using a cell free filtrate of the fungus strain Penicillium aculeatum Su1 as a reducing agent. Parametric optimization of the biosynthesis process demonstrated different effects on the size, distribution, yield, and synthesis rate of biosynthesized AgNPs. The transmission electron microscopy (TEM) measurements demonstrated that AgNPs were spherical or approximately spherical, with a size between 4 and 55nm. High-resolution transmission electron microscopy (HR-TEM) and X-ray diffraction (XRD) analyses indicated that AgNPs were nanocrystalline by nature, with the character of a face-centered cubic (fcc). Fourier transform infrared spectroscopy (FTIR) analysis confirmed the existence of protein molecules that acted as a reducing agent and a capping agent during the biosynthesis process. Furthermore, the biosynthesized AgNPs exhibited higher antimicrobial activity than silver ions against Gram negative bacteria, Gram positive bacteria and fungi. Compared with silver ions, the biosynthesized AgNPs presented higher biocompatibility toward human bronchial epithelial (HBE) cells and high cytotoxicity in a ...Continue Reading

Citations

Dec 20, 2017·Critical Reviews in Biotechnology·Xixi ZhaoMingliang Jin
Feb 28, 2019·Critical Reviews in Analytical Chemistry·Xixi ZhaoChunmei Jiang
May 8, 2020·Biological Trace Element Research·Salem S Salem, Amr Fouda
Mar 11, 2020·Frontiers in Bioengineering and Biotechnology·Radhika ChandankereXianghui Qi
Nov 7, 2019·Frontiers in Bioengineering and Biotechnology·Mariana Guilger-Casagrande, Renata de Lima
Feb 11, 2021·Beilstein Journal of Nanotechnology·Sina Kaabipour, Shohreh Hemmati
Aug 1, 2021·Environmental Science and Pollution Research International·Jayshree AnnamalaiThallada Bhaskar
Apr 9, 2018·ACS Biomaterials Science & Engineering·Li-Yan TaoJin-Song Shi

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