Optimization of a solid-phase microextraction procedure for the determination of herbicides by micellar electrokinetic chromatography

Journal of Separation Science
Sergio Frías-GarcíaMiguel A Rodríguez-Delgado

Abstract

The use of a different optimization procedure that involves Experimental Design (ED) and Artificial Neural Networks (ANN) for the off-line coupling solid-phase microextraction-micellar electokinetic chomatography (SPME-MEKC) is presented. This combination of ED and ANN, mathematical tools not previously used in SPME-MEKC optimization, allowed us to obtain good extraction efficiencies in the SPME procedure for the determination of a group of eleven triazine herbicides in groundwater samples. Both extraction and desorption steps were carried out by solution stirring at 900 rpm. Optimal conditions for the off-line SPME procedure were: extraction with a poly(dimethylsiloxane)/divinylbenzene SPME fiber for 120 min, 10% (w/v) NaCl, desorption time 40 min, and 70% (v/v) of methanol/buffer as desorption mixture. Detection limits lay between 0.80 microg L(-1) and 4.89 microg L(-1). Finally, the optimized method was applied to the determination of these compounds in spiked and non-spiked groundwater samples using a previously optimized MEKC separation.

References

Mar 17, 2000·Journal of Chromatography. a·R Carabias MartínezF Sánchez San Román
Jul 13, 2000·Journal of Chromatography. a·D T Eash, R J Bushway
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Citations

Jul 11, 2006·Journal of Chromatography. a·Carlos Molina-MayoMiguel Angel Rodríguez-Delgado
Dec 17, 2008·Journal of Chromatography. a·Constantine StalikasTriantafyllos Albanis
Sep 9, 2004·Journal of Separation Science·J Hernández-BorgesM A Rodríguez-Delgado
Dec 18, 2014·Biomedical Chromatography : BMC·Abdalla A Elbashir, Hassan Y Aboul-Enein
May 5, 2006·Analytical and Bioanalytical Chemistry·Gangfeng Ouyang, Janusz Pawliszyn
Feb 23, 2007·Journal of Separation Science·Lidia María Ravelo-PérezMiguel Angel Rodríguez-Delgado
Mar 23, 2007·Electrophoresis·Bricio SantosMiguel Valcárcel
Feb 17, 2005·Electrophoresis·Theron J PappasLisa A Holland
May 4, 2007·Electrophoresis·Lidia M Ravelo-PérezMiguel A Rodríguez-Delgado
Oct 25, 2007·Electrophoresis·Lidia M Ravelo-PérezMiguel A Rodríguez-Delgado
Nov 30, 2005·Electrophoresis·Ewa Dabek-Zlotorzynska, Valbona Celo

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