Optimization of a Technique to Standardize the Rodent Roux-En-Y Gastric Bypass Model and Troubleshooting of Postoperative Failures

Obesity Surgery
Qingbo WangZefeng Xia

Abstract

Rodent models are required in studies on the mechanism of Roux-en-Y gastric bypass (RYGB). However, the construction of the model is hard, and there are various causes of death after surgery in rats. RYGB models with procedures containing a series of anatomic landmark were established in rats. Optimized procedures during surgery, possible complications after surgery, and corresponding solutions were studied. With the introduction of perioperative nursing and optimized surgery procedures, less time-consuming surgeries were performed and higher survival rates were achieved. Trouble-shooting data based on death time points are listed and discussed for various causes of failure. This study provides practical suggestions for investigators to perform RYGB surgery on rats. The troubleshooting suggestions will help operators to efficiently identify problems in their procedures.

References

Jul 9, 2004·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael M MeguidPaul R G Cunningham
Jul 18, 2006·Current Surgery·Sukhyung LeeJohn P Schriver
Oct 25, 2006·Annals of Surgery·Nicolas V ChristouLloyd D Maclean
Jul 13, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana GuijarroMichael M Meguid
Dec 11, 2007·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Atul K MadanDavid S Tichansky
Feb 26, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Elizabeth A O'Connor, Arthur M Carlin
Jun 10, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Jose S PinheiroRicardo Cohen
Nov 11, 2008·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·John J Gleysteen
May 27, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Adam T StearnsAli Tavakkolizadeh
Aug 4, 2010·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Patrick GatmaitanStacy A Brethauer
Nov 2, 2011·Obesity Facts·Florian SeyfriedMarco Bueter
Jun 20, 2012·Journal of Visualized Experiments : JoVE·Marco BueterCarel W le Roux
Mar 20, 2013·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Hideharu ShimizuStacy A Brethauer
Sep 4, 2014·JAMA : the Journal of the American Medical Association·Nancy PuzziferriEdward H Livingston
Apr 4, 2015·Obesity Surgery·L AngrisaniN Scopinaro
Jul 28, 2015·Metabolism: Clinical and Experimental·Mohammed K HankirWiebke K Fenske
May 26, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Bárbara G PatrícioMariana P Monteiro

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Surgery
Harutaka InoueJacques Marescaux
Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Hongwei YuZongming Zhang
Archives of Surgery
Attila Csendes
© 2022 Meta ULC. All rights reserved