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Optimization of a yeast RNA interference system for controlling gene expression and enabling rapid metabolic engineering

ACS Synthetic Biology

May 16, 2014

Nathan C CrookHal S Alper

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Abstract

Reduction of endogenous gene expression is a fundamental operation of metabolic engineering, yet current methods for gene knockdown (i.e., genome editing) remain laborious and slow, especially in yeast. In contrast, RNA interference allows facile and tunable gene knockdown via a simple ...read more

Mentioned in this Paper

Gene Expression
Itaconic acid, sodium salt
Gene Knockdown Techniques
Saccharomyces cerevisiae allergenic extract
Organism
Biochemical Pathway
Cosuppression
RNA Conformation
Saccharomyces cerevisiae
Metabolic Process, Cellular
2
117
Paper Details
References
  • References16
  • Citations22
123

Optimization of a yeast RNA interference system for controlling gene expression and enabling rapid metabolic engineering

ACS Synthetic Biology

May 16, 2014

Nathan C CrookHal S Alper

PMID: 24328131

DOI: 10.1021/sb4001432

Abstract

Reduction of endogenous gene expression is a fundamental operation of metabolic engineering, yet current methods for gene knockdown (i.e., genome editing) remain laborious and slow, especially in yeast. In contrast, RNA interference allows facile and tunable gene knockdown via a simple ...read more

Mentioned in this Paper

Gene Expression
Itaconic acid, sodium salt
Gene Knockdown Techniques
Saccharomyces cerevisiae allergenic extract
Organism
2
117

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Paper Details
References
  • References16
  • Citations22
123

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