Optimization of Adhesive Pastes for Dental Caries Prevention

AAPS PharmSciTech
Patteera SodataJomjai Peerapattana

Abstract

Dental caries prevention products available on the market contain only remineralizing agents or antibacterial agents. This study aimed to develop adhesive pastes containing calcium phosphate and α-mangostin for dental caries prevention using the optimization technique. Calcium phosphate was used as a remineralizing agent, and extracted α-mangostin was used as an antibacterial agent. The effect of the independent variables, which were fumed silica, Eudragit® EPO, polyethylene glycol, and ethyl alcohol, on the responses was investigated. The drying time, erosion rate, calcium release rate, and α-mangostin release rate were established as the measured responses. An equation and a model of the relationship were constructed. An optimal formulation was obtained, and its effect on dental caries prevention was investigated using the pH-cycling model. The quadratic equation revealed that the drying time, calcium release rate, and α-mangostin release rate tended to decrease when increasing the fumed silica and decreasing other factors. The erosion rate tended to increase when decreasing Eudragit® EPO and increasing other factors. The observed responses of the optimal adhesive pastes were not significantly different from the predicted res...Continue Reading

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Citations

Feb 23, 2020·BioMed Research International·Wei QiuBiao Ren

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Methods Mentioned

BETA
column chromatography
phosphotransferase

Software Mentioned

FT
ARS
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