Optimization of Antidepressant use with Pharmacogenetic Strategies

Current Genomics
Clara TorrellasRamón Cacabelos

Abstract

The response rate in the pharmacological treatment of depression has been estimated to be around 50%, achieving a remission in symptomatology in only one third of the patients. Suboptimal prescription of antidepressants has been proposed as a significant explanatory factor for this therapeutic inefficacy. The use of pharmacogenetic testing might favor the optimization of pharmacotherapy in emotional disorders. However, its implementation in the clinical routine requires studies which prove its efficacy. The aim is to explore the clinical effects obtained by means of the personalization of antidepressant treatment derived from the pharmacogenetic profile of the individual. A sample of 291 patients under antidepressant treatment was selected, and these patients were genotyped for the most common polymorphisms of the CYP2D6, CYP2C9, CYP2C19 and CYP3A4/5 genes using RT-PCR and TaqMan® technology. 30 of them were subjected to psycho-affective assessment using the HDRS scale before and after a process of individualization of their psychopharmacological treatment in accordance with the genotype obtained. 70% of the individuals treated using the traditional criterion of trial-and-error were not taking the active ingredient most suited ...Continue Reading

Citations

Nov 24, 2018·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Changsu HanAlessandro Serretti
Mar 28, 2019·Expert Review of Clinical Pharmacology·Ramón CacabelosJuan C Carril
May 3, 2020·International Journal of Molecular Sciences·Ramon Cacabelos
Jun 11, 2020·Expert Opinion on Drug Metabolism & Toxicology·Ramón Cacabelos

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Methods Mentioned

BETA
genotyping
pharmacotherapy

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