PMID: 9444447Jan 28, 1998Paper

Optimization of antihypertensive therapy with a novel, extended-release formulation of diltiazem: results of a practice-based clinical study

Clinical Therapeutics
J M NeutelW H Frishman

Abstract

Although the effectiveness of diltiazem for the treatment of patients with hypertension has been well demonstrated in numerous placebo-controlled and comparative clinical trials, most physicians have had some concern about its efficacy and have used it predominantly in patients with mild hypertension. Few large-scale studies have evaluated the efficacy and safety of higher dosages of diltiazem for the treatment of patients with hypertension, and few have evaluated the use of diltiazem in patients with more severe hypertension. Tiazac (Forest Pharmaceuticals, Inc., St. Louis, Missouri), a new, extended-release formulation of diltiazem, provides 24-hour blood pressure control with a single daily dose of up to 360 mg. The Study of Titration and Response to Tiazac (START) is an ongoing practice-based, open-label, multicenter study designed to evaluate the efficacy and safety profiles of Tiazac at greater-than-traditional doses in hypertensive patients and to assess the ability of Tiazac to decrease the rate-pressure product, a surrogate marker for cardiac workload. Patients were eligible for study entry whether their hypertension was newly diagnosed or previously treated with a different formulation of diltiazem or any other antihy...Continue Reading

References

Oct 5, 1988·The American Journal of Cardiology·P E PoolR R Evans
Oct 5, 1988·The American Journal of Cardiology·L AndrénH Wadenvik
Oct 1, 1986·Hypertension·K L SchulteR Gotzen
Dec 6, 1985·The American Journal of Cardiology·W H FrishmanJ Strom

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Citations

Feb 19, 2000·Clinical Cardiology·P E Pool
Mar 15, 2008·The Canadian Journal of Cardiology·Sheldon W TobeUNKNOWN Canadian Hypertension Society
Oct 1, 2003·Journal of Clinical Pharmacology·Suryanarayana SistaKenneth S Albert
Oct 5, 2018·Archives of Craniofacial Surgery·Han Byeol JinJee Hyeok Chung

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