Optimization of axial-pump pressure sensitivity for a continuous-flow total artificial heart

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
O H FrazierWilliam E Cohn

Abstract

In this study, we describe the potential advantages of a continuous-flow total artificial heart (CFTAH) comprising two small, non-pulsatile pumps with optimized responsiveness to the pressure gradient. We modified a MicroMed DeBakey axial-flow pump by increasing its inducer-impeller inlet angle, thereby increasing its pressure responsivity. We obtained the in vitro pressure gradient response and compared it with those of the clinically used, unmodified MicroMed DeBakey pump, Jarvik 2000 FlowMaker and HeartMate II. The modified pump showed an increased response to changes in the pressure gradient at pump flow rates of between 2 and 4 liters/min. The maximum pressure responsivity of the modified pump was 2.5 liters/min/mm Hg; the corresponding maximum responsivities of the Jarvik 2000, HeartMate II and MicroMed DeBakey ventricular assist devices (VADs) were 0.12, 0.09 and 0.38 liters/min/mm Hg, respectively. Because of the inherent properties of non-pulsatile pumps, the CFTAH may potentially respond to changes in inflow and outflow pressures while maintaining physiologic flow rates sufficient for normal daily activity. In addition, the hemodynamic interplay between the two optimized pumps should allow a physiologic response to no...Continue Reading

References

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Jun 23, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·O H FrazierKamuran A Kadipasaoglu
Mar 25, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·O H FrazierKamuran A Kadipasaoglu
Mar 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Santiago GarciaRanjit John
May 23, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hassan A KhalilO H Frazier
May 23, 2008·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hassan A KhalilKamuran A Kadipasaoglu

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Citations

Feb 27, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jeffrey R GoheanRichard W Smalling
Feb 27, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jan PirkIvan Netuka
Jul 4, 2012·Artificial Organs·Mariko KobayashiLeonard A R Golding
Mar 8, 2013·Future Cardiology·Stephen Westaby
Jan 1, 2013·The Annals of Thoracic Surgery·Kiyotaka FukamachiRandall C Starling
Aug 23, 2012·Best Practice & Research. Clinical Anaesthesiology·Shvetank Agarwal, Kane M High
Aug 23, 2012·Best Practice & Research. Clinical Anaesthesiology·Shiva M Sale, Nicholas G Smedira
Apr 16, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Brantley Dollar GaitanAlina M Grigore
Sep 26, 2015·Journal of Cardiac Surgery·Carson S FoxAmy L Throckmorton
Jun 3, 2015·Nature Reviews. Cardiology·William E CohnO H Frazier
Mar 18, 2015·IEEE Journal of Biomedical and Health Informatics·Hui-Lee OoiEinly Lim
May 29, 2016·Medical & Biological Engineering & Computing·Erfan NammakieFarzan Ghalichi
Nov 29, 2008·Seminars in Thoracic and Cardiovascular Surgery·Ranjit John
Mar 26, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Gabriel SayerNir Uriel
Apr 28, 2017·Expert Review of Medical Devices·Ben Bow ChungNir Uriel
Jun 7, 2019·The International Journal of Artificial Organs·Dmitry TelyshevSergey Selishchev
Mar 1, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Guruprasad A GiridharanMark S Slaughter
Nov 28, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·William E CohnO H Frazier
Sep 1, 2017·Journal of Rehabilitation and Assistive Technologies Engineering·Milad HosseinipourMohammad Elahinia
Oct 18, 2016·The International Journal of Artificial Organs·Sergey V Selishchev, Dmitry V Telyshev
May 2, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Vakhtang TchantchaleishviliH Todd Massey
Dec 7, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Wei-Che ChiuDanny Bluestein
Sep 20, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J Ryan StanfieldStacy Bamberg

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