Optimization of beam angles for intensity modulated radiation therapy treatment planning using genetic algorithm on a distributed computing platform.

Journal of Medical Physics
Daryl P NazarethMohammad Bakhtiari

Abstract

Planning intensity modulated radiation therapy (IMRT) treatment involves selection of several angle parameters as well as specification of structures and constraints employed in the optimization process. Including these parameters in the combinatorial search space vastly increases the computational burden, and therefore the parameter selection is normally performed manually by a clinician, based on clinical experience. We have investigated the use of a genetic algorithm (GA) and distributed-computing platform to optimize the gantry angle parameters and provide insight into additional structures, which may be necessary, in the dose optimization process to produce optimal IMRT treatment plans. For an IMRT prostate patient, we produced the first generation of 40 samples, each of five gantry angles, by selecting from a uniform random distribution, subject to certain adjacency and opposition constraints. Dose optimization was performed by distributing the 40-plan workload over several machines running a commercial treatment planning system. A score was assigned to each resulting plan, based on how well it satisfied clinically-relevant constraints. The second generation of 40 samples was produced by combining the highest-scoring samp...Continue Reading

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Citations

Aug 17, 2012·Medical Physics·Wenhua CaoXiaodong Zhang
Feb 10, 2011·Medical Physics·R VaitheeswaranVikram Maiya
Dec 14, 2011·Medical Physics·Nishikant MishraSanthanam Sundar
Apr 7, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Joana DiasMaria do Carmo Lopes
Apr 4, 2015·Medical Physics·Guy AmitVladimir Pekar
May 17, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Agnieszka Skrobala, Julian Malicki
Jan 10, 2013·Medical Physics·Mark BangertUwe Oelfke
Oct 2, 2012·Physics in Medicine and Biology·Mark BangertUwe Oelfke

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