Optimization of coagulometric tests that incorporate human plasma for determination of coagulation factor activities in canine plasma

American Journal of Veterinary Research
R Mischke

Abstract

To optimize methods used to measure coagulation factor activities in canine plasma, define reference ranges in dogs, and compare activities between canine and human plasma. Human plasma samples (n = 5) and plasma from healthy dogs (140) and dogs with low factor V activity (7), high factor V activity (7), and low factor VIII:C activity (6). Coagulometric tests incorporated human plasma deficient in a single coagulation factor (human deficient plasma). Standard curves were generated with pooled plasma from 100 healthy dogs. Effect of sample dilution was evaluated, using plasma from dogs with high or low factor V activity and low factor VIII:C activity. Reference ranges for healthy dogs were established. Activities in human plasma were determined by comparison with standard curves obtained with canine plasma. Activities of factors V and VIII:C in samples diluted < or = 1:20 influenced results of tests for other coagulation factors. Activities of factors V and VIII:C in human plasma were significantly less than in canine plasma. For the other coagulation factors, significant differences in human plasma-to-canine plasma activity ratios were detected among different sample dilutions. Accurate measurement of coagulation factor activit...Continue Reading

References

Nov 1, 1990·Australian Veterinary Journal·P D MansellP J Van Orsouw
Jul 1, 1988·The Journal of Clinical Investigation·D P O'BrienG A Vehar
Jan 1, 1985·Haemostasis·A C ZondagN M Bax
Nov 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·H SaitoO D Ratnoff
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·J H LewisU Hasiba
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·M A KayA R Thompson

❮ Previous
Next ❯

Citations

Feb 3, 2005·The Veterinary Journal·R Mischke
Feb 9, 2011·Veterinary Clinical Pathology·Virginie AllegretChristian Bédard
Nov 28, 2013·American Journal of Veterinary Research·Anna L DengateChristopher M Ward
Oct 19, 2014·BMC Veterinary Research·Valerie M WongR Wood
Jun 3, 2009·The Veterinary Journal·M PrinsE Teske
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·M B CallanK A High
Nov 24, 2011·The Veterinary Journal·Reinhard Mischke
Jan 11, 2011·The Veterinary Journal·Tom KnudsenAnnemarie T Kristensen
Dec 12, 2003·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Reinhard Mischke
Nov 11, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Natali BauerAndreas Moritz
Dec 18, 2018·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Patricia UrbánSusanne Bremer
Mar 17, 2004·The Journal of Toxicological Sciences·Masaaki Kurata, Ikuo Horii
Oct 17, 2017·Journal of the American Veterinary Medical Association·Thomas P KeeshenWilliam T N Culp
Apr 25, 2020·Toxicon : Official Journal of the International Society on Toxinology·Louis Mark EramanisManuel Boller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.