Optimization of coronary attenuation in coronary computed tomography angiography using diluted contrast material

Circulation Journal : Official Journal of the Japanese Circulation Society
Naoto KawaguchiTeruhito Mochizuki

Abstract

The purpose of this study was to evaluate a personalized protocol with diluted contrast material (CM) for coronary computed tomography angiography (CTA). One hundred patients with suspected coronary artery disease underwent retrospective electrocardiogram-gated coronary CTA on a 256-slice multidetector-row CT scanner. In the diluted CM protocol (n=50), the optimal scan timing and CM dilution rate were determined by the timing bolus scan, with 20% CM dilution (5ml/s during 10s) being considered suitable to achieve the target arterial attenuation of 350 Hounsfield units (HU). In the body weight (BW)-adjusted protocol (n=50, 222mg iodine/kg), only the optimal scan timing was determined by the timing bolus scan. The injection rate and volume in the timing bolus scan and real scan were identical between the 2 protocols. We compared the means and variations in coronary attenuation between the 2 protocols. Coronary attenuation (mean±SD) in the diluted CM and BW-adjusted protocols was 346.1±23.9 HU and 298.8±45.2 HU, respectively. The diluted CM protocol provided significantly higher coronary attenuation and lower variance than did the BW-adjusted protocol (P<0.05, in each). The diluted CM protocol facilitates more uniform attenuation ...Continue Reading

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Citations

Mar 30, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Teruhito KidoSachio Kuribayashi
Dec 12, 2018·Radiological Physics and Technology·Jun NakaneKazuhiro Tsuchiya
Nov 13, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Naoto KawaguchiTeruhito Mochizuki

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