Optimization of dose prescription protocol and its impact on delivered dose and vascular response after beta-radiation for in-stent restenosis. A randomized trial with serial volumetric intravascular ultrasound and dose volume histograms

Cardiovascular Revascularization Medicine : Including Molecular Interventions
Adam WitkowskiWitold Ruzyłło

Abstract

The incidence of restenosis within stented segment after intravascular brachytherapy with recommended dose prescription protocols is up to 25%. Therefore, we designed a randomized trial comparing recommended dose prescription protocol with dosing adjusted for the source-to-target distance. Fifty-one in-stent restenosis (ISR) lesions in 48 patients underwent centered source beta-irradiation with serial intravascular ultrasound. Patients randomly received 20 Gy at 1 mm either beyond lumen surface [n=25, standard group (S)] or external elastic membrane [n=26, dosing-adjusted (DA) group]. Minimum dose absorbed by 90% of adventitia (DV(90%Adv)) was calculated. DV(90%Adv) was higher for the DA group than for the S group (21.63+/-5.67 vs. 12.05+/-4.88 Gy, P<.001). After 8.9+/-4.5 months there was complete lumen preservation in DA vs. lumen decrease subsequent to neointimal hyperplasia (NIH) in S group (0.10+/-1.20 vs. -0.61+/-1.29 mm3/mm, P<.05). Vessel volume increased significantly in the DA group and was unchanged in S group (+1.73, P=.002 vs. 0.14 mm3/mm, P=NS). DV(90%Adv) correlated inversely with NIH volume and positively with vessel volume change (r=-.405, P=.007 and r=.363, P=.017, respectively). For beta-irradiation of ISR, d...Continue Reading

References

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