Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers

Pharmaceutics
Elena Cutrín-GómezFrancisco J Otero-Espinar

Abstract

Cyclodextrin/poloxamer-soluble polypseudorotaxane-based nail lacquers have demonstrated significant capacity for promoting the permeation of drugs into the nail plate. Furthermore, previous studies have shown that the use of hydroalcoholic blends as vehicles promotes drug permeation. The work described herein studies the effect of the type of alcohol used in the lacquer preparation, and the composition of the vehicle is optimized to obtain soluble doses of 8% and to promote the diffusion of ciclopirox base and olamine across the nail. Permeation studies on different types of alcohols show that optimum results are achieved with short-chain alcohols, and that results become less satisfactory the higher the number of alcohol carbons. In addition, solubility and penetration studies on the bovine hoof have enabled the composition of the lacquer to be optimized for both forms of ciclopirox. The results suggest that optimized lacquers have better ciclopirox diffusion and penetration properties than the commercial reference lacquer. Lastly, in vivo studies in which optimized ciclopirox olamine lacquer was applied for 45 days to the nails of healthy volunteers showed that it caused no negative effects or changes to the nail surface. The...Continue Reading

References

Nov 1, 1985·The Journal of Pharmacy and Pharmacology·K A WaltersJ R Marvel
Sep 1, 1980·The Journal of Investigative Dermatology·R C Marshall
Sep 1, 1983·The Journal of Investigative Dermatology·H P Baden, J Kubilus
Sep 7, 2004·Journal of Pharmaceutical Sciences·Xiaoying HuiHoward I Maibach
Feb 12, 2005·Drug Development and Industrial Pharmacy·Daniela MontiF Mailland
Aug 27, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·I EffendyUNKNOWN European Onychomycosis Observatory
Nov 12, 2005·Pharmacology·Shuichiro HayashiYuichi Majima
Oct 12, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hemali B Gunt, Gerald B Kasting
Sep 13, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·L Nogueiras-NietoF J Otero-Espinar
Dec 21, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Luis Nogueiras-NietoFrancisco J Otero-Espinar
Dec 4, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Luis Nogueiras-NietoFrancisco J Otero-Espinar
Jun 28, 2014·AAPS PharmSciTech·Biji B PalliyilDavid B Lebo
Dec 19, 2014·Pharmaceutical Development and Technology·Sudhir M BaswanGerald B Kasting
Feb 18, 2016·Journal of Pharmaceutical Sciences·Sudhir M BaswanGerald B Kasting
Aug 19, 2015·Journal of Fungi·Jenna N Queller, Neal Bhatia
Mar 5, 2018·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Elena Cutrín GómezFrancisco J Otero Espinar
Apr 21, 2018·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Elena Cutrín GómezFrancisco J Otero Espinar

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Methods Mentioned

BETA
Profiler
confocal optical microscopy

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