Optimization of dual-wavelength intravascular photoacoustic imaging of atherosclerotic plaques using Monte Carlo optical modeling

Journal of Biomedical Optics
Nicholas DanaStanislav Emelianov

Abstract

Coronary heart disease (the presence of coronary atherosclerotic plaques) is a significant health problem in the industrialized world. A clinical method to accurately visualize and characterize atherosclerotic plaques is needed. Intravascular photoacoustic (IVPA) imaging is being developed to fill this role, but questions remain regarding optimal imaging wavelengths. We utilized a Monte Carlo optical model to simulate IVPA excitation in coronary tissues, identifying optimal wavelengths for plaque characterization. Near-infrared wavelengths (≤1800  nm) were simulated, and single- and dual-wavelength data were analyzed for accuracy of plaque characterization. Results indicate light penetration is best in the range of 1050 to 1370 nm, where 5% residual fluence can be achieved at clinically relevant depths of ≥2  mm in arteries. Across the arterial wall, fluence may vary by over 10-fold, confounding plaque characterization. For single-wavelength results, plaque segmentation accuracy peaked at 1210 and 1720 nm, though correlation was poor (<0.13). Dual-wavelength analysis proved promising, with 1210 nm as the most successful primary wavelength (≈1.0). Results suggest that, without flushing the luminal blood, a primary and secondary ...Continue Reading

References

Oct 20, 1975·Biochimica Et Biophysica Acta·B W Matthews
Dec 1, 1989·IEEE Transactions on Bio-medical Engineering·S T FlockM S Patterson
Jul 1, 1995·Computer Methods and Programs in Biomedicine·L WangL Zheng
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·J M Sun, B S Gerstman
Dec 20, 2002·Nature·Peter Libby
Jun 1, 2005·The American Journal of Medicine·Shomron Ben-HorinAvi Livneh
Dec 10, 2009·Optics Express·Jimmy Li-Shin SuStanislav Y Emelianov
Feb 2, 2010·The Review of Scientific Instruments·Andrei B KarpioukStanislav Y Emelianov
Mar 1, 1973·Applied Optics·G M Hale, M R Querry
Aug 7, 2012·Interface Focus·Paul Beard
Jan 1, 1999·Journal of Biomedical Optics·A RogganG Mu Ller
Dec 12, 2012·Journal of Biomedical Optics·Doug YeagerStanislav Emelianov
May 15, 2013·Physics in Medicine and Biology·Steven L Jacques
Jan 30, 2014·Journal of Biomedical Optics·Da-Kang YaoLihong V Wang
Feb 14, 2014·Journal of Biomedical Optics·Krista JansenGijs van Soest
Oct 11, 2014·Photoacoustics·Krista JansenGijs van Soest
Oct 29, 2014·IEEE Transactions on Biomedical Circuits and Systems·Maxime AbranFrederic Lesage
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 15, 2017·Computers in Biology and Medicine·Sun ZhengHan Duoduo

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